Fin-ceramica Faenza S.p.a.

Consiglio Nazionale Delle Ricerche

Claudio De Luca

Anna Tampieri

Daniele Pressato

Elena Landi

Jordan N Jacobs

Simone Sprio

Sergio Di Fede

Elisa Figallo

Giancarlo Celotti

An apparatus and kit for making holes of controlled depth and different diameters on chondral and osteochondral surfaces, comprises: a reamer member () having a cutting head () for removing tissue from said chondral and osteochondral surface (A), said member () being mobile approaching the chondral and osteochondral surface (A) for arranging the head () at said tissue; guide means () for guiding the reamer member () that can be firmly associated with the chondral or osteochondral surface (A), said reamer member () being slidable along said guide means (); and mechanical means () for controlling the depth of the hole interposed between the reamer member () and the guide means () for defining an end stop of the reamer member () in the respective movement towards said chondral and osteochondral surface (A).

Apparatus and kit for making holes at controlled depth and of different diameters on chondral and osteochondral surfaces

The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses.

Plurisubstituted hydroxyapatite and the composite thereof with a natural and/or synthetic polymer, their preparation and uses thereof

The present invention relates to a multilayer structure () including a first upper layer () consisting of an organic matrix including collagen and at least a lower layer () consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure () as well as an osteochondral substitute including said multilayer structure (). Finally, the present invention relates to the use of said multilayer structure () for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.

Cartilaginous and osteochondral substitute comprising multilayer structure and use thereof

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Padua, Italy

Claudio De Luca