Calder Biosciences Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Avatar Medical

Claudio Bertuccioli

Peter Joseph Alff

Christopher P Marshall

Jason Scott McLellan

Roberto Mariani

Mark Andrew Yondola

Christopher Marshall

Jason Scott Mclellan

Christopher Patrick Marshall

In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Conformationally stabilized RSV pre-fusion F proteins

In some embodiments the present invention provides influenza hemagglutinin ('HA') polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

Influenza hemagglutinin proteins and methods of use thereof

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New York, NY, United States of America

Claudio Bertuccioli