H. Lee Moffitt Cancer Center and Research Institute, Inc.

The Wistar Institute

Claudio Anasetti

Dmitry Gabrilovich

Scott Antonia

Frederick L Locke

Said M Sebti

Nicholas James Lawrence

Harshani Lawrence

Dario C Altieri

Brian Betts

Joseph Pidala

Dario Altieri

The invention concerns a variant (double mutant form) of the survivin polypeptide; nucleic acid molecules encoding the survivin variant; antigen presenting cells (APCs) such as dendritic cells, or APC precursors, comprising the variant survivin polypeptide or encoding nucleic acid sequence; and methods for treating a malignancy, such as myeloma, or for inducing an immune response, utilizing a variant survivin polypeptide, nucleic acid molecule, or APC.

Variant survivin vaccine for treatment of myeloma

Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible T. In certain aspects, disclosed are compounds of Formula I-V.

Aurora kinase and janus kinase inhibitors for prevention of graft versus host disease

Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible T. In certain aspects, disclosed are compounds of Formula I-V. 

Aurora kinase and Janus kinase inhibitors for prevention of graft versus host disease

Double mutant survivin vaccine

Growing community of inventors

Saint Petersburg, FL, United States of America

Claudio Anasetti