Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Institut Des Vaisseaux Et Du Sang

Gencell Sas

Claudine Soria

He Lu

Michel Perricaudet

Patrice Yeh

Pierre Jolles

Jeannette Soria

Ludovic O Drouet

Thierry Ragot

Yves Legrand

Paule Opolon

Frank Griscelli

Hong Li

Christelle Mabilat

Anne-Marie Fiat

Levy-Toledano Sylviane

Elisabeth Mazoyer

Sanghamitra Raha

Véronique Trochon

A method of inhibiting angiogenesis or invasion or formation of metastases in a mammal including administering a therapeutically effective amount of an active agent selected from the group consisting of a protein substance including all or part of a disintegrin domain of an adamalysin or a derivative thereof, a nucleic acid molecule including a polynucleotide sequence coding all or part of the disintegrin domain of an adamalysin or a derivative thereof to the mammal.

Method of inhibiting angiogenesis or invasion or formation of metastases

The present invention relates to gene therapy for the treatment of tumors. The invention more particularly relates to introduction of a gene encoding an anti-angiogenic factor into cells of a tumor, for example with a defective adenovirus vector, to inhibit growth or metastasis, or both, of the tumor. In a specific embodiment, delivery of a defective adenovirus that expresses the amino terminal fragment of urokinase (ATF) inhibited growth and metastasis of tumors. These effects were correlated with a remarkable inhibition of neovascularization within, and at the immediate vicinity of, the injection site. Delivery of a defective adenovirus vector that expresses kringles 1 to 3 of angiostatin inhibited tumor growth and tumorigenicity, and induced apoptosis of tumor cells. The invention further provides viral vectors for use in the methods of the invention.

Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors

The peptides according to the invention are of the following general formula I:

Tetra- and pentapeptides containing the lysyl-arginyl-aspartyl sequence

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Taverny, France

Claudine Soria