Sanofi-aventis

Sanofi-synthelabo

Sanofi

Elf Sanofi

Claudine Serradeil-Le Gal

Jean Wagnon

Gerard Valette

Richard Roux

Loic Foulon

Georges Garcia

Bernard Tonnerre

Bruno Schoentjes

Gilles Courtemanche

Pierre Despeyroux

Alain Pellet

Bernard Christophe

Pierrick Rochard

Evelyne Fontaine

Loïc Foulon

Alain Di Malta

Alain Aulombard

Antoine Pradines

Denis Brasseur

Gareth Shackleton

Gérard Valette

G&eacute;rard Valette

Lo&iuml;c Foulon

Cedric Couturier

Brigitte Pouzet

Laurent Goullieux

The present invention relates to novel 3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, to their preparation and to their therapeutic application. The compounds of the present invention correspond to the formula (I): in which the variables are as set forth in the specification. These compounds exhibit a strong affinity and a high selectivity for human arginine-vasopressin (AVP) Vreceptors and some compounds additionally exhibit a strong affinity for AVP Vreceptors.

3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, preparation thereof and therapeutic use thereof

The subject matter of the present invention are compounds corresponding to formula (I):  in which: X is an unsubstituted or substituted divalent (C-C)alkylene radical; Ris an &#x2014;NRRgroup; or an unsubstituted or substituted piperidin-3-yl or piperidin-4-yl radical; Ris a hydrogen atom, a halogen atom, an Alk group or an OAlk group; Ris a hydrogen atom, a halogen atom, an Alk group or an OAlk group; Ris a hydrogen atom, a halogen atom, an Alk group, a hydroxyl or an OAlk group; and Ris a hydrogen atom, a halogen atom, an Alk group, a hydroxyl or an OAlk group.

[object Object]

The present invention is directed to a compound of formula (I): wherein Ar, Ar, Ar, R1 and T are as defined herein, its preparation, pharmaceutical composition and uses as orexin 2 receptor antagonist.

Sulfonamide derivatives, preparation thereof and use thereof as antagonists of orexin 2 receptors

The subject of the present invention is a compound of formula (I): in the base, hydrate or solvate state, in the form of cis/trans isomers or of mixtures thereof, preparation and therapeutic use thereof.

3-spiroindolin-2-one derivatives, preparation and therapeutic use thereof

The disclosure concerns indolin-2-one pyridine compounds of general formula (I): wherein R, R, R, R, R, Z and B have the meanings given in the description, and pharmaceutically acceptable salts thereof; and also pharmaceutical compositions comprising, processes for making and methods of using said compounds.

Indolin-2-one pyridine derivatives, preparation and therapeutic use thereof

The invention relates to compounds of formula: and to solvates and/or hydrates thereof, with affinity for and selectivity towards the Vreceptors or both the Vand Vreceptors of arginine-vasopressin. The invention also relates to a process for preparing them, to the intermediate compounds of formula (II) which are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

1,3-dihydro-2H-indol-2-one derivatives, process for preparing them and pharmaceutical compositions containing them

Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barr&#xe9; syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

Sulphonamide derivatives, their preparation and their therapeutic application

The invention relates to compounds of formula: as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and selectivity towards the Vreceptors or towards both the Vand Vreceptors of arginine-vasopressin. The invention also relates to the process for preparing them, to the intermediate compounds of formula (II) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for the preparation of medicinal products.

The invention relates to acyloxypyrrolidine derivatives of general formula (I): in which:

Acyloxypyrrolidine derivatives, preparation thereof and application thereof in therapeutic

1,3-dihydro-2H-indol-2one derivatives, process for preparing them and pharmaceutical compositions containing them

The invention relates to compounds of formula:  and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin Vreceptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the Vreceptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula:and to solvates and/or hydrates thereof, with affinity for and selectivity towards the Vreceptors or both the Vand Vreceptors of arginine-vasopressin. The invention also relates to a process for preparing them, to the intermediate compounds of formula (II) which are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

1,3-dihydro-2H-indol-2-one derivatives, method for preparing same and pharmaceutical compositions containing them

1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for V1b and V1a arginine-vasopressin receptors

Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands

1,3-dihydro-2H-indol-2-one derivatives, preparation method and pharmaceutical composition containing them

Growing community of inventors

Escalquens, France

Claudine Serradeil-Le Gal