Evonik Degussa Gmbh

Claudia Rollmann

Helge Werner

Karlheinz Drauz

Thomas Haas

Arne Skerra

Werner Hummel

Jan Christoph Pfeffer

Volker Sieber

Harald Gröger

Harald Groeger

Kai Doderer

Katrin Grammann

Alexandra Lerchner

Hendrik Hüsken

Broder Rühmann

Broder Ruehmann

Christian Rausch

Francoise-Christine Chamouleau

Dittmar Orzewski

Francoise Chamouleau

Chad Hagedorn

Françoise Chamouleau

Nicolas Orologas

The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.

Method for producing multicyclical ring systems carrying amino groups

A product is enriched by a method for the processing of a reaction solution, in which: a) a pH value of the reaction solution is adjusted to less than 4; wherein said reaction solution comprises a whole-cell catalyst, an aqueous component, and an organic component, wherein the organic component contains a product to be enriched; and b) the reaction solution is filtered in the presence of a filter aid, thereby enriching the product.

Processing of reaction solutions from whole-cell biotransformations

The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.

Coupled cofactor-dependent enzymatic reaction systems in aqueous media

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Alzenau, Germany

Claudia Rollmann