University of Toronto

University Health Network

Claudia Regina Gordijo

Xiao Yu Wu

Xiaoyu Wu

Azhar Z Abbasi

Mohammad Ali Amini

Huiyu Huang

Preethy Prasad

Kai Zhang

Ralph S Dacosta

Azusa Maeda

Jason Siu-Wei Li

Michael Kl Chu

Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.

Multifunctional nanoparticle compositions and uses thereof

A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component.

Implantable-glucose responsive insulin delivery device

Growing community of inventors

Toronto, Canada

Claudia Regina Gordijo