M Et P Pharma Ag

Mattern Pharma Ag

M & P Patent Aktiengesellschaft

Harro Hofliger Verpackungsmaschinen Gmbh

Cum Pharma Consulting Anstalt

Mattern, Claudia

Claudia Mattern

Elisabeth Traiffort

Michael Schumacher

Markus Bohn

Achim Götz

Thomas Joos

Udo Mattern

Wilfried Pieper

Achim Gotz

Described herein are nasal pharmaceutical compositions comprising a porous excipient and an active agent, wherein the active agent is loaded onto a surface of the porous excipient located inside pores of the porous excipient, and wherein the composition is adapted for nasal administration. Also described herein are methods of making and using nasal pharmaceutical compositions.

Nasal pharmaceutical compositions with a porous excipient

Described herein are methods of promoting remyelination in a subject suffering from demyelination diseases by administering to the subject a combination of steroid hormones and Hedgehog signaling pathway modulators. Also described are methods of administering the combination of drugs, wherein the combination of drugs are in compositions adapted for nasal administration.

Treatment of demyelinating diseases

Described herein are methods for reducing the risks of exposure to air pollutants, comprising nasally administering to a subject in need thereof a composition that counteracts the effects of one or more air pollutants, wherein the composition is adapted for nasal administration. In some embodiments the composition comprises an agent that binds to one or more air pollutants, wherein the agent comprises one or both of nonporous silicon dioxide and porous silicon dioxide and/or the composition provides a physical barrier between one or more air pollutants and internal nasal surfaces. Also described are nasal compositions comprising an agent comprising one or both of nonporous silicon dioxide and porous silicon dioxide, a lipophilic or partly lipophilic vehicle, and a surfactant, wherein the composition is adapted for nasal administration. The compositions also may comprise other agents, such as an immunosuppressant. Also described are methods of making and using the compositions.

Nasal pharmaceutical compositions for reducing the risks of exposure to air pollutants

This invention relates to a gel formulation for nasal administration of a controlled release formulation of hormones to the systemic circulation and/or to the brain. The special lipophilic or partly lipophilic system of the invention leads to higher bioavailability of the active ingredient caused by sustained scrum levels in plasma but also leads to a more favorable serum level profile. The special lipophilic or partly lipophilic system also allows for the modulation of brain functioning. The invention also relates to the nasal administration of steroid hormones for treatment of female sexual dysfunction (FSD) or female arousal disorder.

Controlled release delivery system for nasal applications and method of treatment

This invention relates to a galenical gel formulation for nasal administration of neurotransmitters/neuromodulators such as dopamine, serotonin or pregnenolone and progesterone. The special lipophilic or partly lipophilic system of the invention leads to high bioavailability of the active ingredient in plasma and brain caused by sustained serum levels and/or direct or partly direct transport from nose to the brain.

Controlled release delivery system for nasal application of neurotransmitters

The invention relates to a filling and closing device () for an applicator for active substances () and to a method for filling and closing such an applicator for active substances () by means of such a filling and closing device (). The applicator for active substances () comprises an applicator tube () that overlaps the sealing edge (), at least in part. The filling and closing device () comprises a receiving element () for the lower part () of the applicator for active substances (), having a circumferential pressure surface () and a receiving channel () for the applicator tube (), said receiving channel extending below the pressure surface (). The receiving element () is constructed of at least two parts, having a base element () and a cover element () that is movable with respect to the base element (). After completion of the filling and sealing process, the cover element () is moved relative to the base element (), such that the receiving channel () formed therebetween is exposed. The filled and sealed applicator for active substances () can then be easily removed from the receiving element () by way of the applicator tube ().

Filling and closing device, and method for filling and closing an applicator for active substances

This invention relates to a gel formulation for nasal administration of a controlled release formulation of hormones to the systemic circulation and/or to the brain. The special lipophilic or partly lipophilic system of the invention leads to higher bioavailability of the active ingredient caused by sustained serum levels in plasma but also leads to a more favorable serum level profile. The special lipophilic or partly lipophilic system also allows for the modulation of brain functioning. The invention also relates to the nasal administration of steroid hormones for treatment of female sexual dysfunction (FSD) or female arousal disorder.

This invention relates to a pernasally administrable preparation for the controlled release of sexual hormones to the systemic circulation, in particular to a formulation which enables its active ingredient to be absorbed in a sustained manner providing a better bioavailability at very low doses and longer duration of action.

Controlled release delivery system for nasal applications

Controlled release delivery system for nasal applications and methods of treatment

The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.

Growing community of inventors

Emmetten, Switzerland

Claudia Mattern