Vito Nv

Claudia Matassa

Yamini Satyawali

Dominic Ormerod

Karolien Vanbroekhoven

Helmut Elslander

A method and a device are disclosed for converting at least one reactant into a reaction product and separating the at least one reactant. The device includes a vessel with a vessel inner volume and a confinement, submerged in the vessel inner volume, that provides a confinement inner volume in fluid connection with the vessel inner volume. First and seconds fluids, with a respective, higher first density and a lower, second density form respective lower and upper phases in the vessel inner volume. A third fluid with a third density higher than that of the second fluid forms a lower layer in the confinement inner volume, relative to an upper layer formed by the second fluid. The third fluid may be the same as or different from, and is physically separated from, the first fluid. At least one of the first, second, and third fluids is at most partly miscible with the other two, but preferably immiscible. The at least one reactant and the reaction product have different affinities for at least two of the first, second, and third fluids, and at least one of the first and third fluid contains a fourth phase which is a solid or semi solid and is capable of promoting the conversion.

Device and method for converting and separating at least one reactant and a reaction product thereof

A method for producing a chiral amine may include performing a transamination reaction of a prochiral amino acceptor and an amino donor in a first solution in the presence of a transaminase, thereby forming a chiral amine and a co-product in the first solution. The amino donor is a high molecular weight (HMW) amino donor. In some examples, the molecular weight of the HMW amino donor is at least 150 g/mol. In some examples, the amino donor is affixed on a support, the total molecular weight of the amino donor and the support being at least 150 g/mol.

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Mol, Belgium

Claudia Matassa