Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Kg

Claudia Heine

Thierry Bouyssou

Kurt Schromm

Ingo Konetzki

Andreas Schnapp

Sabine Pestel

Frank Buettner

Hermann Schollenberger

Christoph Hoenke

Klaus Rudolf

Philipp Lustenberger

Ralf Anderskewitz

Horst Dollinger

Niklas Heine

Kai Gerlach

Herbert Nar

Christian Eickmeier

Franz Birke

Pascale Pouzet

Hans Michael Jennewein

Bernd Disse

Alexander Weber

Pascale Arielle Jane-Josee Pouzet

The present invention relates to dihydropteridinones, their use as modulators of &#x3b3;-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with &#x3b3;-secretase and/or its substrate and therefore modulate the formation of A&#x3b2; peptides.

Dihydropteridinones I

A pharmaceutical composition comprising a compound of formula 1 wherein:

Medicaments for the treatment of chronic obstructive pulmonary disease

The present invention relates to the use of the compounds of general formula 1 wherein the groups R, X and Y may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition for the treatment of COPD (chronic obstructive pulmonary disease), as well as new compounds of general formula 1 and processes for preparing them.

3-hydroxymethyl-4-hydroxy-phenyl-derivatives for the treatment of respiratory diseases

Disclosed are compounds of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar, Ar, A, R, R, R, E, E, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.

Pyrrolidinohydrochinazolines

A compound of formula 1 wherein the groups R, R, R, and Rmay have the meanings given in the claims and in the specification, processes for preparing them, and their use as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.

Dihydroxymethylphenyl derivatives, processes for preparing them, and their use as pharmaceuticals

A compound of formula 1wherein: Ris C-C-alkyl; Ris C-C-alkyl; and Ris C-C-alkyl or phenyl, each optionally mono- or polysubstituted, or Rand Rtogether are &#x2014;CH&#x2014;CH&#x2014; or &#x2014;CH&#x2014;CH&#x2014;CH&#x2014;, or the corresponding acid addition salt with a pharmacologically acceptable acid, processes for preparing such compounds, pharmaceutical compositions containing such compounds, and their use in the treatment of inflammatory and obstructive respiratory diseases.

Betamimetics with a prolonged duration of activity, processes for preparing them, and their use as pharmaceutical compositions

The invention concerns benzimidazole derivatives of the general formula (I)in which the radicals R, R, R, Xand A can have the meanings assigned to them in the specification, their prodrugs, processes for their production as well as the use of the benzimidazole derivatives as medicines, especially as medicines that have trypsin-inhibiting action.

Benzimidazole derivatives, a process for their manufacture and use as a medicine

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Biberach, Germany

Claudia Heine