Aventis Pharma Deutschland, Gmbh

Sanofi-A Ventis Deutschland Gmbh

Aventis Pharmaceuticals Inc.

Claudia Eder

Luigi Toti

Michael Kurz

Herbert Kogler

Sabine Haag-Richter

Mark Br&ouml;nstrup

The present invention relates to spirobenzofuran lactam derivatives of the formula I which are formed during fermentation by the microorganismST002348, DSM 14952, processes for their preparation, their use as pharmaceuticals, and the microorganismST002348, DSM 14952.

Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof

The invention relates to compounds of the formula (I)process for their preparation starting from the plant, PLA 101037, and the use thereof for producing a medicament, in particular for the treatment of allergic disorders, of asthmatic disorders, of inflammatory concomitant symptoms of asthma and/or of diseases which can be treated by inhibiting c-maf and NFAT.

Endiandric acid H and its derivatives, process for their preparation and use thereof

Eurotinones, and derivatives thereof, processes for preparing them, and their use

The present invention provides novel drechsleranol compounds of formula (I) which are formed by the microorganism , ST 003360, DSM 14093, or a fungus ST 004112, DSM 14524, during fermentation. A process for their preparation, pharmaceutical compositions containing said drechsleranols their use for the treatment and/or prophylaxis of degenerative neuropathies, such as, Alzheimeu's disease, or psychiatric disorders, such as depression, sleep disturbance or seasonal affective disorder, and their use as chelating agents or antioxidants are also disclosed and claimed.

Drechsleranol derivatives, processes for their preparation and their use

The present invention relates to novel caloporoside derivatives and method of their use. The caloporoside derivatives may be formed by fermentation of microorganisms, such as (Fr.: Fr.) Bres. ST001714 (DSM 13784). The invention also relates to use to a process for preparing caloporoside derivatives, drugs comprising such compounds, and methods of their use. The invention further relates to the microorganism Bres. ST001714 (DSM 13784).

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Hofheim, Germany

Claudia Eder