Bracco Imaging S.p.a.

Claudia Cabella

Luigi Miragoli

Silvio Aime

Valentina Mainero

Pernille Rose Jensen

Magnus Karlsson

Fabio Tedoldi

Sonia Colombo Serra

Simonetta Chirich Geninatti

Alessandro Maiocchi

Roberta Napolitano

Massimo Visigalli

Simona Ghiani

Mathilde H Lerche

Luisa Poggi

Chiara Brioschi

Lara Caminiti

Luca Venturi

Lerche H Mathilde

1-C-1,1-Bis(acetoxy(methyl))-2,2'-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent inC Magnetic Resonance diagnostic technique (C-MR) for the diagnosis of tumor.

Hyperpolarized 1-13C-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for MR

The invention relates to a method of Magnetic Resonance (MR) detection, in particularC-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarizedC carboxylic ester and of its respective hyperpolarized metabolite.

Hyperpolarized esters as metabolic markers in MR

The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.

Paramagnetic solid lipid nanoparticles (pSLNs) containing metal amphiphilic complexes for MRI

The invention provides MRI detectable species of formula (I)D-S-N&#x2003;&#x2003;(I)wherein These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.

Agents for magnetic imaging method

The invention provides MRI detectable species of formula (I): D-S-N, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer, m is an integer and p is an integer. These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.

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Pecco, Italy

Claudia Cabella