Technion Research & Development Foundation Ltd

Bristol-myers Squibb Compnay

Senomyx, Inc.

Exelixis Patent Company LLC

Claudia Averbuj

Moris S Eisen

Edith Tish

Victoria Volkis

Michal Shmulinson

Raju Mohan

Catherine Tachdjian

Vincent Darmohusodo

Qing Chen

Andrew P Patron

Nicholas Ronald Wurtz

Xiao-Qing Tang

Ellen K Kick

Farid Bakir

Brett Bradley Busch

Chad Priest

Sara L Adamski-Werner

Rhondi Shigemura

Meriah Neissel Valente

Mandar Shrikrishna Bodas

Rachel D A Kimmich

Marketa Lebl-Rinnova

Prasanna Savanor Maddu Rao

Alla Venu

Jeevanprakash Shetty

Rachel D Kimmich

The present invention provides compounds of Formula I and Formula II: or pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXRs), and compositions comprising any of such novel compounds and methods of use thereof. These compounds are useful as medicaments for treatment and/or prophylaxis for diseases or conditions related to activity of LXRs. 

LXR modulators

The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.

Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers

A process for the polymerization of one or more alpha-olefins having at least 3 carbon atoms, which comprises contacting the monomer or monomers in a polar or non-polar solvent under polymerization conditions with a homogeneous catalyst system including (a) a cationic form of a racemic mixture of a chiral octahedral transition metal complex or of a non chiral octahedral transition metal complex, comprising 1, 2 or 3 bidentate chelating ligands and no cyclopentadienyl ligands and having C , C , or C symmetry; and (b) an anion of a Lewis acid or a Br&ouml;nsted acid; and adjusting the pressure so as to obtain either a highly stereoregular polymer or copolymer or an elastomer.

Process for the production of stereoregular polymers and elastomers of alpha-olefins and certain novel catalysts therefor

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Claudia Averbuj