Rhone-poulenc Chimie

Rhodia Chimie

Rhone-poulenc Agrochimie

Centre National De La Recherche Scientifique

Rhone-poulenc Specialites Chimiques

Electricite De France - Service National

Rhone-poulenc Specialties Chimiques

Claude Wakselman

Marc Tordeux

Bernard Langlois

Catherine Francese

Nicolas Roques

Jean-Louis Clavel

Roland Nantermet

Laurent Saint-Jalmes

Gerard Forat

G&eacute;rard Forat

Laurent Petit

Amaya Berecibar

Hatem Marzouk

Huguette Molines

A reagent comprising a compound of formula (I): R &mdash;M(X)(Z) &mdash;Y&mdash;R, wherein R is a hydrocarbon radical advantageously having at most 10 carbon atoms and being selected from alkyls and aryls; R is a radical of formula II: R &mdash;(C&Xgr; ) &mdash;CF &mdash;, where R is a fluorine or chlorine atom or a carbon radical, m is 0 or a integer from 0-12, and each &Xgr;, which may be the same or different, is a chlorine or preferably fluorine atom, with the proviso that when m is 0, R is electroattractive, preferably a fluorine atom; n is 0 or 1; M is a non-metal selected from carbon and chalcogens with an atomic number than oxygen; and each of X, Y and Z, which are the same or different, is a chalcogen; as well as a generator, for consecutive or simultaneous addition. The reagent is useful for organic synthesis.

Reactant, compound and process for the perfluoroalkylation of a nucleophile, and the derivatives obtained

The invention concerns a method for the condensation of aromatic derivative(s) or a sulphinic derivative by a perhalogenated, advantageously perfluorinated, carbon atom. Said method is characterized in that it consists in subjecting said sulphinic derivative and said aromatic derivative to the action of a strong acid whereof the pKa is not more that 0. The invention is applicable to organic synthesis.

Method for condensation of aromatic derivative(s) and a sulphinic derivative

Reactant, compound and process for the perfluoroalkylation of the

Method for preparation of perfluoroalcanecarboxylic and

The present invention relates to a process for the preparation of perhaloalkylthioethers by bringing a perhaloalkyl halide, preferably a bromide or an iodide, into contact with a disulphide in the presence of zinc and of sulphur dioxide or of a dithionite or of a hydroxymethanesulphinate or of a formate anion and sulphur dioxide.

Process for the preparation of perhaloalkylthioethers

A class of compounds, namely 1-fluoro-1-halo-3,6-dioxabicyclo[4.1.0]heptanes and a process using these compounds in the preparation of fluoromalonaldehyde acetals. The 1-fluoro-1-halo-3,6-dioxabicyclo[4.1.0]heptane is brought into contact with an alcohol in an acid medium. The fluoromalonaldehyde acetals obtained are also new products, which are useful for the synthesis of alkyl fluoromalonates or of fluorinated nitrogen-containing heterocycles.

1-fluoro-1-halo-3,6-dioxabicyclo [4.1.0]heptane preparation, process and

A process for the preparation of perhaloalkanesulfinic and -sulfonic acids and derivatives of these acids. A perhaloalkanesulfinic acid salt is prepared by contacting a metal hydroxymethanesulfinate (preferably, a sodium, zinc or copper hydroxymethanesulfinate) with a perhaloalkyl halide group, in a polar solvent. Optionally, the perhaloalkanesulfinic acid salt is then converted to a perhaloalkanesulfinic or -sulfonic acid or a derivative of either of these acids.

Process for the preparation of perhaloalkanesulfinic and -sulfonic

A process for the preparation of perfluoroalkylated ketones and/or perfluoroalkylated alcohols, comprising the step of contacting a perfluoroalkyl iodide or perfluoroalkyl bromide with an acid anhydride, in the presence of a metal chosen from zinc and cadmium.

Process for perfluoroalkylation of acid anhydrides

A process for the preparation of a perfluoroalkyl ketone. A perfluoroalkyl halide, zinc and an ester are brought into contact with one another. Preferably a polar aprotic solvent and/or a pyridine is also present.

Process for the preparation of perfluoroalkyl ketones

A process for the preparation of trifluoromethyl iodide by bringing into contact with one another to form a reaction product either:

Process for the preparation of trifluoromethyl iodide

A process for the preparation of a benzyl trifluoromethyl sulfide by bringing a benzyl thiocyanate and trifluoromethyl bromide into contact with zinc in a polar aprotic solvent or a pyridine. The invention also relates to a process for the preparation of trifluoromethane sulfonyl chloride by bringing a benzyl trifluoromethyl sulfide into contact with chlorine and water.

Process for the preparation of benzyl trifluoromethyl sulfide

A process for the perfluoroalkylation of aromatic derivatives. In a first stage, an aromatic derivative, sulfur dioxide and a metal selected from the group consisting of zinc, aluminum, manganese, cadmium, magnesium, tin, iron, nickel and cobalt, are brought into contact in a solvent, preferably a polar aprotic solvent. In a second stage, a perfluoroalkyl bromide or iodide is added to react with the aromatic derivative.

Process for perfluoroalkylation of aromatic derivatives

A process for the preparation of perfluoroalkylated alcohols and esters by bringing a carbonyl-containing derivative and a perfluoroalkyl iodide or bromide into contact with zinc, preferably in the presence of a polar aprotic solvent and/or a pyridine.

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Paris, France

Claude Wakselman