Centre National De La Recherche Scientifique

Agence Nationale De Valorisation De La Recherche (anvar)

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Adir Et Compagnie

Societe De Conseils De Recherches Et D'applications Scientifiques

Albert Rolland S.a.

Claude Thal

Pierre Potier

Catherine Guillou

Henri P Husson

Dolor Renko

Pierre Lestage

Jean Lepagnol

Jean-Daniel Brion

Jean-Gilles Parmentier

Luc Demuynck

Thierry Sevenet

Henri-Philippe Husson

Jean-Pierre Zanetta

Monique Sensenbrenner

Catherine Quirosa-Guillou

Marie-Madeleine Portier

Christophe Labriere

Herbert Koenig

Janine Koenig

Pascal Schmitt

Jean-Francedillaois Pujol

Emmanuel Gras

Frank Kozielski

Francoise Gueritte

Sergey Tcherniuk

Dimitrios Skoufias

Jean-Luc Beunard

Joanna Bakala

Daniel Guenard

Pierre Jean-Paul Potier

Yves Christen

Maria Conception Achab

Nobumichi-André Sasaki

Gisèle Franck

Olivier Boye

Aude Mary

Richard Besselievre

Andre Hugelin

Nobumichi-Andre Sasaki

Maria Conception I/achib

Françoise Gueritte

The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Use of derivatives of indoles for the treatment of cancer

The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R=a hydrogen atom, R=a hydroxy group, Rand Rtogether form &#x2550;O, R, R, and Rindependently=a hydrogen atom, a hydroxy group or a (C-C)alkoxy group, R&#x2550;H, (C-C)alkyl, (CH)NRR, or &#x2014;(CH)NRRRwhere n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a &#x2014;SO, &#x2014;SO, or &#x2014;NRgroup where Ris as defined above or is an amine protecting group.

Total synthesis of galanthamine, analogues and derivatives thereof

The present invention relates to the use of biguanide derivatives of general formula I below: in which:

Use of biguanide derivatives for making a medicine having a wound healing effect

The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R=a hydrogen atom. R=a hydroxy group, Rand Rtogether form &#x2550;O, R, R, and Rindependently=a hydrogen atom, a hydroxy group or a (C&#x2013;C)alkoxy group, R&#x2550;H, (C&#x2013;C)alkyl, (CH)NRR, or &#x2014;(CH)N'RRRwhere n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a &#x2014;SO, &#x2014;SO, or &#x2014;NRgroup where Ris as defined above or is an amine protecting group 

Galanthamine derivatives, and their pharmaceutical compositions

Guanidine derivatives are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies. The compounds have the formula: ##STR1## wherein R.sub.1 is an isopropyl radical, a benzyl radical which is optionally substituted by one or more (C.sub.1 -C.sub.6)alkoxy radicals or a radical: ##STR2## R.sub.2, R.sub.3 and R.sub.4 together with the nitrogen atoms to which they are attached and the carbon atom to which the said nitrogen atoms are attached form a pyrimidine ring of formula II or a pyrimidinium ring of formula IIa: ##STR3##

Compounds having a guanidine structure and pharmaceutical composition

A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description, the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.

Benzopyrrolizinoquinolizinones

A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,

EburnanE analogues

Compounds having a guanidine structure

Phenylpyrrolic compounds used as drugs, their preparation and application

Compositions and method of treating neuropathies resulting from diabetic, non-diabetic, toxic or viral origin and insuring regeneration of damaged nerve fibers by administration of the N,N-dimethyl-biguanide salt of p-chlorophenoxy-acetic acid.

Novel pharmaceutical compositions intended to the treatment of

Pentacyclic derivatives of the general formula ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow are useful as cerebral protectors and vasodilators.

Vasodilating octahydro-1,12-methano-oxymethano[2,3-a]-indoloquinolizines

New compounds having the formula ##STR1## in which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula : ##STR2## in which R is H or C.sub.2 H.sub.5.

Vincamine derivatives

New compounds having the formula ##SPC1## In which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula: ##SPC2## In which R is H or C.sub.2 H.sub.5.

Vincamine derivatives and process for the preparation of vincamine and

Growing community of inventors

Sceaux, France

Claude Thal