Pci Biotech as

The Norwegian Radium Hospital Research Foundation

Claude Rimington

Kristian Berg

Pal Kristian Selbo

Greta Rimington, Legal Representative

Diem Thuy Thi Tran

The present invention provides photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin, preferably a disulphonated meso-tetraphenylporphyrin such as TPPS. The resulting sulphonated meso-tetraphenyl chlorins include compounds of formula I: (wherein The compounds of the invention and their pharmaceutically acceptable salts find particular use as photosensitizing agents in the photochemical internalization of molecules and in photodynamic therapy.

Compound

The present invention provides photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin, preferably a disulphonated meso-tetraphenylporphyrin such as TPPS. The resulting sulphonated meso-tetraphenyl chlorins include compounds of formula (I) (wherein X is &#x2014;SOH; n, p, q and r are each independently 0 or 1; and the sum of n, p, q and r is an integer from 1 to 4, preferably at least 2, e.g. 2 or 4) isomers and isomer mixtures thereof. The compounds of the invention and their pharmaceutically acceptable salts find particular use as photosensitizing agents in the photochemical internalization of molecules and in photodynamic therapy. 

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Son, Norway

Claude Rimington