Behringwerke Aktiengesellschaft

Other

Centre National De La Recherche Scientifique

Les Laboratoires Servier

Sanofi Sa

Laboratoires Hoechst S/a

Laboratories Hoechst S.a.

Hoechst Aktiengesellschaft

Adir Et Compagnie

Institute Curie

Heochst Aktiengesellschaft

Laboratoires Hoechst

Claude Monneret

Jean-Claude Florent

Klaus Bosslet

Jean-Claude Jacquesy

Michel Koch

Jean-Pierre Gesson

Francedillaois Tillequin

Dieter Hoffmann

Jorg Czech

Michel Azoulay

Alain Pierre

Bruno Pfeiffer

Cenek Kolar

Emile R Bisagni

David Grierson

Pierre Renard

Ghanem Atassi

John Hickman

Pierre M Roger

Jean-Paul Fournier

Patrick Choay

Manfred Gerken

Anne-Marie Aubertin

Chi Hung Nguyen

Philippe Meresse

J Org Czech

Emmanuel Bertounesque

Gerhard Dickneite

Gerhard Seemann

Hans H Sedlacek

Abdellah Benjahad

Hans-Ulrich Schorlemmer

Laurence Kraus-Berthier

Dominique Mabire

Martine Mondon

Daniel Dauzonne

Alain Martin

Rainer Straub

Roland Hoos

Dieter Hoffman

Valerie Dolle

Pierre Benard

Frederic Schmidt

Jérôme Guillemont

Brigitte Renoux

Gilbert Gaudel

Agnes Genot

Chi Hung N'Guyen

Gérard Sanz

Laurence Decrane

Val&eacute;rie Dolle

The invention relates to compounds of formula (I), wherein Ris a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)R, Y is a group selected from HN&#x2014;NH and N&#x2014;R, Ris a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, Ris hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof 

9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives

The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, Calkyl or Calkenyl; X is (a-2) with q and r being O and Z being O, S or SO; Ris aryl; Ris selected from formyl; Calkyloxycarbonylalkyl; Het; HetCalkyl, Calkylthio; Calkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; Ris selected from formyl; Calkyl optionally substituted with one or two Calkyloxy; Ris hydrogen, with HTV inhibiting properties 

Pyridinone and pyridinethione derivatives having HIV inhibiting properties

A compound selected from these of formula (I):wherein:

Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them

3-(amino-or aminoalkyl) pyridinone derivatives and their use for the treatment of HIV related diseases

The present invention is concerned with 3-(amino- or aminoalkyl)pyridinone derivatives which inhibit the reverse transcriptase of the Human Immunodeficiency Virus (HIV). It relates moreover to the use of such compounds for treating HIV-related diseases. Furthermore it relates to a process for the preparation of these compounds.

3-(Amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of HIV related diseases

9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-&lsqb;3&prime;,4&prime;:6,7&rsqb;naphtho&lsqb;2,3-d&rsqb;&lsqb;1,3&rsqb;dioxol-6(5aH)-one compounds

Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.

Prodrugs, their preparation and use as pharmaceuticals

Prodrugs their preparation and use as pharmaceuticals

Prodrugs for the therapy of tumors and inflammatory disorders

Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.

Pro-prodrugs, their production and use

Enzymatically clearable prodrugs with reduced Michaelis-Menten constant (Km) are described.

Prodrugs for enzyme mediated activation

Glycosylated prodrugs, their method of preparation and their uses

The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R' can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R' represents hydrogen, and R' and R' cannot be simultaneously hydrogen atoms. These compounds present an antitumor activity.

Process for preparing nitrosourea derivatives

The present invention relates to new tetralins and their use for the preparation of anthracyclinones and anthracyclins. These tetralins contain at least one chiral carbon atom and correspond to the formula (V) below: ##STR1## in which: R.sub.1 and R.sub.2 denote a hydrogen atom, or a halogen atom or the group OCH.sub.3, provided that one of the two substituents (R.sub.1 or R.sub.2) must denote OCH.sub.3, and

2',6'-Dideoxy derivatives of anthracycline glycosides

The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an --NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an --NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R' can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R' represents hydrogen, and R' and R' cannot be simultaneously hydrogen atoms.

Nitrosourea derivatives, process for their preparation and medicaments

Growing community of inventors

Paris, France

Claude Monneret