Eli Lilly and Company

Smithkline Corporation

Smithkline Beckman Corporation

Claude H Nash, Iii

Kenneth M Snader

David J Cooper

Marcia C Shearer

Joseph R Valenta

Stephen W Queener

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragile Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by streptosporangium fragile

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by Streptosporangium fragilis Shearer

A procedure for efficiently obtaining higher mycophenolic-acid-producing mutants from mycophenolic-acid-producing strains of the genus Penicillium by selecting mutants which are resistant to polyene antibiotics.

Procedure for obtaining penicillium species mutants with improved

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Audubon, PA, United States of America

Claude H Nash, Iii