Rhone-poulenc Sante

Other

Rhone-poulenc Rorer S.a.

Rhone-poulenc, Inc.

Rhone-poulenc Rorer Pharmaceuticals Inc.

Claude Gueremy

Serge Mignani

Patrick Jimonet

Jean-Luc Malleron

Jean-Francois Peyronel

Alain Truchon

Marie-Therese Comte

Francois Audiau

Gerard Ponsinet

Christian L Renault

Conception Nemecek

Didier G Wirth

Francoise Maillard

Marie-Iherese Comte

Bruno Musch

Joseph Le Blevec

Maurice Auclair

Robert Labey

##STR1## Compounds of formula (I), in which R.sub.1 is a polyfluoralkoxy, R.sub.2 is a sulphur or nitrogen atom substituted by an alkyl radical or a sulfonyl or sulfinyl radical, R.sub.3 is a phenyl, benzoyl, --NR.sub.4 R.sub.5 or piperidinyl-4radical substituted in position 1 by a phenylalkyl radical, R.sub.4 is an alkyl radical, R.sub.5 is a phenylalkyl radical, n is equal to 1, 2 or 3, m is equal to 0, 1, 2 or 3. The present invention also relates to the salts of said compounds, processes for the preparation of the latter and drugs containing them.

Benzothiazole derivatives and medicinal products containing them

Compounds of formula: ##STR1## in which R.sub.1 represents a substituted 1-piperazinyl, substituted 1,2,3,6-tetrahydro-1-pyridyl or substituted piperidino radical, R.sub.2 represents a polyfluoroalkoxy or a polyfluoroalkyl radical and n is equal to 2 or 3, the salts of these compounds with an acid, processes for preparing them and medicinal products containing them.

2-imino-3-alkylbenzothiazoline derivatives bearing a heterocyclic

Compounds of formula: ##STR1## in which R.sub.1 represents a polyfluoroalkoxy radical and R.sub.2 represents an alkylthio, alkylsulphinyl or alkylsulphonyl radical, their salts, their preparation and the medicaments containing them.

3-(3-alkylthiopropyl)benzothiazoline derivatives, their preparation and

This invention relates to compounds of formula: ##STR1## in which R.sub.1 denotes

Serotonin antagonists, their preparation and medications containing them

Heterocyclic derivatives, their preparation and medicinal products

This invention relates to a compound of the formula: ##STR1## in which R.sub.1 represents

Derivatives of (AZA) naphthalensultam, their preparation and

Compounds of formula: ##STR1## and their salts, in which R.sub.1 represents polyfluoroalkoxy, and R.sub.2 represents alkyl, alkenyl (3-6 C), [cycloalkyl (3-6 C)]-alkyl, carbamoylalkyl, dialkylcarbamoylalkyl, acylaminoalkyl, phenylthioalkyl, hydroxyalkyl, cyanoalkyl, sulphamoylethyl, N-alkylsulphamoylethyl, pyridylthioalkyl, pyridiylalkylthioalkyl, pyridylsulphinylalkyl, alkynyl (3-6 C), phenylsulphinylalkyl, halophenylthioalkyl, (2,2,2-trifluoroethylthio)alkyl, 2-dialkylaminopropyl, pyrimidinylsulphinylalkyl, pyridylalkylsulphinylalkyl, halophenylsulphinylalkyl or (2,2,2-trifluoroethylsulphinyl)alkyl are useful in the treatment of medical conditions associated with the effects of glutamate.

2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharmaceutical

This invention relates to a compound ##STR1## in which R.sub.1 represents

Derivatives of (AZA)naphthalenesultam, their preparation and

Compounds of the formula: ##STR1## in which - R.sub.1 denotes a polyfluoroalkoxy or polyfluoroalkyl radical, and - R.sub.2 denotes either a chain --CH.sub.2 --(CH(R.sub.4)).sub.n --R.sub.3, in which R.sub.3 denotes a dialkylamino, piperidino, 1-pyrrolidinyl, mercapto, acylthio, alkylthio, alkylsulphinyl or alkylsulphonyl radical, R.sub.4 denotes a hydrogen atom or an alkyl radical and n is equal to 0 or 1,

2-iminobenzothiazoline derivatives, their preparation and pharmaceutical

Compounds of formula: ##STR1## in which: either R.sub.1 represents 4-phenyl-1,2,3,6-tetrahydro-1-pyridyl or 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-pyridyl, R.sub.2 represents hydrogen, alkoxy of 1 or 2 carbon atoms, hydroxyl, alkyl, alkylthio, alkylcarbonyloxy, phenylalkylcarbonyloxy, phenylalkyl or --NR.sub.4 R.sub.5 in which R.sub.4 represents hydrogen or alkyl and R.sub.5 represents alkyl, phenyl, monohalogenated phenyl or pyridyl, and R.sub.3 represents a hydrogen atom, or else R.sub.2 represent phenyl and R.sub.3 represents hydrogen or hydroxyl;

Isoindolinone derivatives, processes for preparing them and medicines

2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharamaceutical

2-amino-6-(trifluoromethoxy)benzothiazole or a pharmaceutically accpetable salt thereof is useful for the treatment of schizophrenia, particularly the negative forms thereof.

Use of a compound for the treatment of schizophrenia

Phenothiazine derivatives are described of the formula ##SPC1## In which X.sub.1 and X.sub.2, which may be the same or different, are H, R, F, Cl, Br, OR, CN, --COR, CH.sub.3, --S--R, --SOR, --SO.sub.2 R or --SO.sub.2 N(CH.sub.3).sub.2, where R is an alkyl group having from 1 to 4 carbon atoms, and the quinuclidine ring is substituted by the group --(CH.sub.2).sub.x -- in the 2- or 3- position, x being 1 or 2 when said group is substituted in the 2-position and being 0 or 1 when said group is substituted in the 3-position (because of electronic hindrance), and their acid addition and quaternary ammonium salts, have valuable pharmacological properties. In particular, these compounds have anti-histaminic, anti-cholinergic, adrenolytic, neuro-sedative, tranquillizing and/or spasmolytic properties. These compounds are prepared by condensing an appropriate phenothiazine with a quinuclidine derivative of the formula ##SPC2## In which x has the above-stated meaning and Z is a halogen atom or a reactive ester group.

Phenothiazine derivative

Compounds having anti-inflammatory and antipyretic action have the general formula ##SPC1## In which each of R.sub.1 and R.sub.2 is a phenyl group which may be substituted by a halogen atom, an alkyl or alkoxy group having 1 to 4 carbon atoms or a trifluoromethyl group, R.sub.3 is a straight or branched chain saturated or unsaturated aliphatic hydrocarbon group or a cycloaliphatic hydrocarbon group having 3 to 7 carbon atoms, or a benzyl or phenyl group which benzyl or phenyl groups may be substituted in the benzene ring by a halogen atom, an alkyl or alkoxy group having 1 to 4 carbon atoms or a trifluoromethyl group or by any two of these substituents, R.sub.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and A is a group having one of the formulae --COOH, --COOR.sub.5 and --CONR.sub.6 R.sub.7 in which R.sub.5 is an alkyl group having 1 to 4 carbon atoms or a benzyl group and each of R.sub.6 and R.sub.7 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms or R.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are attached represents a pyrrolidino, a piperidino or a morpholino group.

Growing community of inventors

Houilles, France

Claude Gueremy