Expansia

Societe D'etudes De Produits Chimiques

'societe Anonyme' Expansia

Claude G Demosthene

Christian R Aspisi

The invention relates to the preparation process of 2-isopropylamino pyrimidine consisting in reaction at room temperature, 2-amino pyrimidine on acetone in the presence of an organic carboxylic acid, and of an excess of an alkaline borohydride.

Process for the preparation of 2-isopropylamino pyrimidine

The present invention provides a process for the synthesis of 2-isopropylamino-pyrimidine by aminolysis of 2-methylsulphonyl-pyrimidine using isopropylamine. The aminolysis is effected, according to the present invention, by refluxing isopropylamine and 2-methylsulphonyl-pyrimidine in the absence of a solvent. Using this technique, the 2-isopropylamino-pyrimidine has been obtained in a substantially quantitative yield.

Synthesis of 2-isopropylamino-pyrimidine

Preparation process of 2-chloro pyrimidine from 2-amino pyrimidine, hydrochloric acid and an alkali metal nitrite, the reagents being in substantially similar proportions as in the previously known methods, consisting in preparing a mixture of hydrochloric acid and of a non polar solvent of low boiling point, then adding 2-amino pyrimidine wherein there is slowly added, at room temperature, the chloride of a metal selected from the group consisting of the transition metals, tin, antimony, thallium and zinc, then introduced, under an inert gas circulation, the selected nitrite at a temperature not exceeding 10.degree. C. and finally poured the reaction mixture in iced water.

Preparation process of 2-chloro pyrimidine

New bis-thioaralkyl/alkyl alkyl boranes for use in hydroboration and reduction reactions are disclosed. They have the formula:

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Aramon, France

Claude G Demosthene