Imatx, Inc.

Claude Donald Arnaud

Daniel Steines

Philipp K Lang

Rene Vargas-Voracek

Siau-Way Liew

Barry Jonathan Linder

A method of predicting bone or articular disease in a subject includes determining one or more micro-structural parameters, one or more macroanatomical parameters or biomechanical parameters of a joint in the subject and combining at least two of the parameters to predict the risk of bone or articular disease.

System and method for predicting future fractures

This disclosure relates to methods and devices for analyzing x-ray images. Futhermore, bone condition of a subject can be evaluated by analyzing x-ray images of the subject's bone and therapies can then be selected or devised for the subject.

Methods and devices for evaluating and treating a bone condition on x-ray image analysis

Methods of diagnosing and preventing bone loss and/or enhancing bone formation are disclosed. The invention additionally provides methods of diagnosing a predisposition to bone loss. The methods mathematically combine the information provided by imaging tests with the information provided by biomarkers to provide an index value. The index value is used for diagnosis of bone diseases, and to assess the progress of treatment of bone diseases.

Methods to diagnose treat and prevent bone loss

Methods of predicting fracture risk of a patient include: obtaining an image of a bone of the patient; determining one or more bone structure parameters; predicting a fracture line with the bone structure parameter; predicting a fracture load at which a fracture will happen; estimating body habitus of the patient; calculating a peak impact force on the bone when the patient falls; and predicting a fracture risk by calculating the ratio between the peak impact force and the fracture load. Inventive methods also include determining the effect of a candidate agent on any subject's risk of fracture.

System and method of predicting future fractures

The present invention relates to methods and devices for evaluating bone conditions based on images. In particular, devices, methods and algorithms are provided that allow for the accurate and reliable evaluation of bone structure from x-ray images.

Methods and devices for evaluating and treating a bone condition based on X-ray image analysis

This disclosure relates to methods and devices for analyzing x-ray images. Furthermore, bone condition of a subject can be evaluated by analyzing x-ray images of the subject's bone from a sliding region of interest (ROI), e.g., an ROI that is moved on a pixel-by-pixel basis on the image, and therapies can then be selected or devised for the subject.

Methods and devices for evaluating and treating a bone condition based on x-ray image analysis

Methods of predicting fracture risk of a patient include: obtaining an image of a bone of the patient; determining one or more bone structure parameters; predicting a fracture line with the bone structure parameter; predicting a fracture load at which a fracture will happen; estimating body habitus of the patient; calculating a peak impact force on the bone when the patient falls; and predicting a fracture risk by calculating the ratio between the peak impact force and the fracture load. Inventive methods also includes determining the effect of a candidate agent on any subject's risk of fracture.

Described herein are methods for analyzing bone structure and/or bone density, methods for estimating fracture risk in a subject as well as methods for monitoring the efficacy of an agent on bone structure and/or bone density.

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Mill Valley, CA, United States of America

Claude Donald Arnaud