Adir Et Cie

Adir, S.a.r.l.

Claude Cudennec

Gilbert Lavielle

Georges Remond

Michel Vincent

Bernard Portevin

Guillaume Le Baut

Jean-Daniel Brion

Patrick Hautefaye

Genevieve Seurre

Patrick Ducrey

Sylvie Piessard-Robert

The invention relates to the compounds of general formula: ##STR1## in which: X denotes either an oxygen atom, or two hydrogen atoms;

Tripeptide compounds having a nitrogenous polycyclic structure

Compounds of general formula (I): ##STR1## in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group,

New heteroarotinoid compounds

Tetrapeptide compounds of general formula: ##STR1## in which R denotes:

Peptide compounds having a nitrogenous polycyclic structure

The invention relates to N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid of general formula I ##STR1## in which: R.sub.1 denotes a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkylene radical containing from 1 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and capable of bearing a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidzolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms,

N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid useful for

The invention relates to tetrapeptide derivatives of the general formula ##STR1## in which R represents a hydrogen atom, a straight-chain or branched alkyl radical containing from 1 to 5 carbon atoms, optionally substituted by a hydroxy, amino, mercapto, methylthio, methylsulphoxide, carboxy or guanidino group, or a benzyl or indol-3-ylmethyl radical optionally substituted by a hydroxy group,

New oxaazaphosphorine compounds corresponding to the formula: ##STR1## in which R is alkyl, cycloalkyl or alkoxy,

Oxaazaphosphorine compounds and pharmaceutical compositions

New nitrosourea compounds that can be used as medicaments and correspond to the general formula I ##STR1## in which R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or phenyl,

Growing community of inventors

La Celle St. Cloud, France

Claude Cudennec