Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Boston Scientific Neuromodulation Corporation

Commissariat a L'energie Atomique

Université Grenoble Alpes

Centre Hospitalier Universitaire Grenoble Alpes

Claude Chabrol

Sarah Renault

Michael A Moffitt

Emanuel Feldman

Dennis Allen Vansickle

Adam Thomas Featherstone

Adrien Poizat

John Rivera

Alim-Louis Benabid

Nicolas Aubert

Laurent Duraffourg

Patrick Pouteau

Patrice Caillat

Jean-Yves Laurent

Pierre Labeye

Mathieu Dupoy

Herve Denis

Stephan Chabardes

Quentin Mermillod-Ansleme

Pierre Bleuet

Julien Routin

Cécile Moro

Alim Louis Benabid

Quentin Borntrager

Clémentine Fulbert

An optically stimulating module to be integrated into a probe is implantable into a living being with a view to locally illuminating a region of said living being. The module includes a casing that is at least partially transparent, and a hermetic electronic unit placed in the casing. The hermetic electronic unit includes an internal volume housing two light sources, a control and processing unit, and a first photodetector. The module also includes a connecting device for connecting the module to a central control and power unit.

Illuminating device implantable in a living being

An optical stimulation system includes a light source configured to produce light for optical stimulation; a light monitor; an optical lead coupled, or coupleable, to the light source and the light monitor; and a control module coupled, or coupleable, to the light source and the light monitor. The control module includes a memory, and a processor coupled to the memory and configured for receiving a request for verification or measurement of a light output value; in response to the request, receiving, from the light monitor, a measurement of light generated by the light source; and, based on the measurement, reporting a response to the request.

Optical stimulation system with on-demand monitoring and methods of making and using

An optically stimulating module to be integrated into a probe is implantable into a living being with a view to locally illuminating a region of said living being. The module includes a casing, and a hermetic electronic unit housed in the casing. The hermetic electronic unit includes two luminous diodes connected back-to-back, and at least two electrical contacts for connecting the module to an electrical power source.

A device for cooling locally, including a cooling member, a crystal having the capacity to cool via absorption of a near-infrared exciting light signal, an illuminating system intended to deliver an exciting light signal, the crystal having an elongate shape about a longitudinal axis between a near end and a far end and having a closed constant outside cross section and containing a central channel formed, from its far end, over at least some of its length, the cooling member including a rod embedded via a first end into the central channel of the crystal and including a protruding second end that forms a cooling finger.

Device for cooling locally

An optical stimulation system includes a light source; an optical lead coupled, or coupleable, to the light source; at least one of a calibration table or a calibration formula, generated by a calibration procedure specifically using the light source and the optical lead of the optical stimulation system; and a control unit coupled, or coupleable, to the light source. The control module includes a memory to store the at least one of the calibration table or the calibration formula, and a processor coupled to the memory and configured for receiving a target light output level, using the at least one of the calibration table or the calibration formula to determine at least one operational parameter for generating the target light output level, and directing the light source, using the at least one operational parameter, to generate light at the target light output level.

Optical stimulation systems with calibration and methods of making and using

The invention relates to an implantable illuminating device intended to be implanted in a living being with a view to locally illuminating a region of said living being, said device including a probe, said architecture being characterized in that it is produced from: an optical fiber that comprises a core, a cladding and a protective coating, a jacket, said architecture including: a plurality of successive segments along its longitudinal axis, each segment having a section containing a plurality of concentrically superposed layers, in which each segment includes a section containing a plurality of superposed layers that is different from the section of each adjacent segment.

Implantable localised illuminating device with improved architecture

The invention relates to a device for cooling an organ locally, that includes an elongate stem including a far end intended to make contact with an organ to be cooled and comprising including a cooling element having a cold finger, a crystal that has a capacity to cool via excitation at a set excitation wavelength, said crystal being positioned adjacent to said cooling element, an optical guide that is able to convey a light signal at said excitation wavelength and that opens onto said crystal, and an illuminating system including at least one light source, which light source is arranged to emit said light signal.

Device for localized cooling of an organ

The invention relates to a device comprising: a light source mounted in a housing, the housing comprising a transparent window opposite the light source; an optical fiber fitted with a connector suitable for detachably engaging with the housing to retain an input surface of the optical fiber opposite the light source via the window; and an interface element made of transparent elastomeric material suitable, in the connected position, for being retained so as to be compressed between the window and the input surface of the optical fiber.

Device for optically stimulating the brain via an optical fiber

The invention relates to an implantable device for optical stimulation of an organ of the human or animal body, having a probe comprising a tube made of a first transparent material, this tube being hermetically closed by at least one stopper; at least one light source arranged inside the tube; a plurality of electrical connection elements extending through the stopper and electrically connecting said at least one light source to the outside of the tube; and a linking cable arranged outside the tube and connected to said connection elements.

Implantable device for optical stimulation of the brain

The invention relates to a device for detecting a leak in a sealed enclosure, comprising an organic light-emitting diode intended to be placed inside the enclosure; and a device for measuring a value representative of at least one of the following parameters: a) the luminous efficacy of the diode; and b) the impedance of the diode.

Device for detecting a leak in a sealed enclosure

A deep brain stimulation device includes a probe having a transparent distal portion, crossed by a channel open at a proximal end of the probe, and also includes electrodes affixed to the distal portion of the probe and electrode terminals affixed to a proximal portion of the probe. Further, the device includes an electrical housing including a channel open at its two ends and housing electrical terminals in contact with the terminals of the probe, and an electrical extension lead affixed to the housing and connected to the terminals of the housing. The channel of the housing is open at the other one of its ends and the device further includes a waveguide at least partly housed in the central channel of the probe, all the way to the distal portion of the probe, and a transmitter housing capable of being connected to the waveguide for the injection of a predetermined wavelength.

Device for deep electrical and optical brain stimulation

The invention concerns an integrated-structure device for transmitting optical waves comprising a plurality of optical microguides (), a plurality of notches () with coupling surfaces through which respectively emerge said optical microguides; optical fibers whereof the end parts are respectively arranged and fixed in said notches so as to optically couple the end surfaces of said optical fibers and said coupling surfaces of said optical microguides; said coupling surfaces () of said notches () extend perpendicular to said integrating planes and are slanting relative to the longitudinal direction of the end part () of the optical fiber () and/or of said optical micro-guide () and are aligned; said end surfaces () of said optical fibers () extend parallel to said coupling surfaces () of said notches () and are aligned.

Device for transmitting optical waves with inclined coupling surfaces

A device for the positioning and holding of an optical fiber having a substrate, a groove for receiving the optical fiber, and at least one first and one second groove widenings along a longitudinal axis of said groove. An adhesive substance is introduced in one of the two widenings, said adhesive substance fixing the fiber to the substrate. A process for fixing a fiber to a substrate includes the steps of positioning the fiber, holding said fiber with a tool, and introducing an adhesive substance for fixing the fiber to a substrate.

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Poisat, France

Claude Chabrol