Laboratoires Chauvin-blache

Roussel Uclaf

Claude Bonne

Claude Coquelet

Daniel Sincholle

Jacques Perronnet

Alain Alazet

Andre Teche

Pierre Girault

Elisabeth Battais

Samia Roussillon

New derivatives of 4-vinyl benzoic acid, process for their preparation

The subject of the invention is N-substituted 2-aminothiazoles of formula ##STR1## in which: X is a C--H group or a nitrogen atom,

N-substituted 2-amino-thiazoles, process for their preparation and their

Amidines, preparation process and therapeutical application thereof

This invention relates to a therapeutic composition comprising, as active ingredient, a compound of the formula (I) ##STR1## in which R is hydrogen or an ether or ester residue, or a therapeutically acceptable acid addition salt thereof. This composition is applicable to the treatment and the prevention of thromboses.

Etheral imidazoles and use in treatment of thromboses

Antiandrogenic compositions comprising an effective amount of at least one compound of the formula ##STR1## wherein X and Y are individually selected from the group consisting of hydrogen, halogen, --CF.sub.3, --NO.sub.3 and alkylthio of 1 to 4 carbon atoms and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, benzyl and hydroxymethyl and an inert pharmaceutical carrier and a method of inducing antiandrogenic activity in warm-blooded animals as well as novel oxadiazines of formula I with the proviso that when R is other than benzyl or hydroxymethyl at least one of X and Y is alkylthio of 1 to 4 carbon atoms.

3-Oxo-5,6-dihydro-1,2,4-oxadiazines useful as antiandrogenic agents

Imidazolidines of the formula ##STR1## wherein X is selected from the group consisting of oxygen and amine which inhibit the effects of androgens on peripheric receptors without interfering with normal hypophysial functions.

1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl imidazolidines

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Bry-sur-Marne, France

Claude Bonne