Columbia University

University of Missouri

Clark T Hung

Eric G Lima

James L Cook

Aaron Stoker

Gerard A Ateshian

Mark A Borden

Melvin P Rosenwasser

Brian K Jones

Shashank Ramesh Sirsi

Li Ming Bian

Grace D O'Connell

The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.

Tissue preservation system

A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.

Customized bendable osteochondral allografts

A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.

Microbubble devices, methods and systems

The present disclosure provides cell culture medium comprising trimethylamine N-oxide (TMAO). Progenitor cells cultured with such medium can form connective tissue with enhanced mechanical properties. Also provided are methods of forming connective tissue and methods of treatment for connective tissue defects.

Tissue culture method for producing cartilage using trimethylamine N-oxide and chondroitinase

Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.

Growing community of inventors

Ardsley, NY, United States of America

Clark T Hung