USA As Represented by Secretary of the Navy

Tessarae, LLC

Clark J Tibbetts

David A Stenger

Baochuan Lin

Zheng Wang

Gary J Vora

Brian K Agan

Donald Seto

Jennifer Johnson

Eric H Hanson

Dzung C Thach

Russell P Kruzelock

Elizabeth A Walter

Robb K Rowley

The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample.

Re-sequencing pathogen microarray

An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CCD having an imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire microarray.

Microarray imaging system and associated methodology

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Sperryville, VA, United States of America

Clark J Tibbetts