The J. David Gladstone Institutes

Buck Institute for Research on Aging

Clare Peters-Libeu

Varghese John

Dale E Bredesen

Yadong Huang

Karl H Weisgraber

Qin Xu

Thu Nga Bien-Ly

Ligong Chen

In certain embodiments compositions are provided that comprise a pentapeptide comprising the formula: C-X-X-X-Cwhere Cand Care independently selected cysteines or cysteine analogues, or other amino acids with sidechains suitable for cyclization, where the cysteines or cysteine analogs are attached to each other by a linkage that does not comprise X, X, and X; where X, X, and Xare independently selected amino acids; and the peptide, when administered to a cell alters APP signaling and/or switches APP processing from aberrant to normal. The compositions mitigate amyloid plaque formation.

Netrin loop peptide mimetics and uses thereof

The present disclosure provides synthetic antibodies specific for an epitope present on an apolipoprotein E polypeptide. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.

Antibody specific for apolipoprotein and methods of use thereof

Growing community of inventors

Sebastopol, CA, United States of America

Clare Peters-Libeu