Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Vetmedica Gmbh

Clara K Miao

Edward S Lazer

Julian Adams

Peter Farina

Karl D Hargrave

Cornelia Dorner-Ciossek

Roger John Snow

Klaus Klinder

Karl G Grozinger

Robert Rothlein

John P Devlin

Genus J Possanza

Marcus Kostka

Klaus Bornemann

Frank Sams-Dodd

Ronald Faanes

Dagmar Kugler

Guenter Trummlitz

Bernd Beck

Ian F Potocki

Thomas P Parks

A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid &#x3b2; peptides (A&#x3b2;) and/or with a changed ratio of levels of A&#x3b2; isoforms and/or with the formation of plaques containing amyloid &#x3b2; peptide (A&#x3b2;) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R, R, R, R, L1 and i are defined as in claim

Method of treating diseases and conditions associated with an altered level of amyloid &#x3b2;  peptides and new enolcarboxamide compounds

This invention relates to 4-substituted .beta.-carbolines and .beta.-carboline analogs that inhibit Ca.sup.+2 influx and interleukin-2 (IL-2) production. The 4-substituted .beta.-carbolines and .beta.-carboline analogs of this invention are represented by formula (I): ##STR1## wherein Q, n, R, R', R' and R.sub.1 -R.sub.4 are as defined herein. This invention also relates to methods for producing .beta.-carbolines. Because of their selective immunomodulating properties, the compounds and pharmaceutical compositions of this invention are particularly well suited for preventing and treating immune disorders, including autoimmune disease, inflammatory disease, organ transplant rejection and other disorders associated with IL-2 mediated immune response.

4-substituted beta-carbolines and analogs thereof

Various substituted benzoxazoles and benzothiazoles, are described and disclosed, which are potent inhibitors of leukotriene synthesis in warm-blooded animals.

Leukotriene biosynthesis inhibitors

Various substituted benzoxazoles, benzothiazoles, oxazolopyridines and thiazolopyridines are described and disclosed, compounds that are potent inhibitors of leukotriene synthesis in warm-blooded animals.

Novel thienylbenzylamine compounds of the formula ##STR1## wherein A and R.sub.1 -R.sub.5 are defined herein. These compounds are useful for the treatment of inflammation.

Anti-inflammatory thienylbenzylamine compounds

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Trumbull, CT, United States of America

Clara K Miao