The University of Arizona

Dermspectra LLC

Raytheon Company

George Mason University

Techara LLC

Tochara LLC

Clara Curiel

Karleen Seybold

Karim Alami

Michael Patton

Brian Lau

Cory R Boudreau

Vladlena Belozerova

Ivans S Chou

Frederick C Mertz

Robert K Pina

Emanuel F Petricoin, III

Bill Dorr

Lawrence C DePaula

Amanda Fern Baker

Sally E Dickinson

Michael Bertino

Karleen Seybould

Karleen G Seybold

The present invention relates to a method of using family and/or regulatory members of the PD-1/PD-L1 pathway as predictive markers for risk of skin cancer development and as targets for therapeutic prevention of pre-malignant (or pre-cancerous) skin lesions and non-melanoma skin cancer (NMSC). This invention will allow for quantitative measurements of UV-induced expression of PD-1/PD-Li signaling pathway family members (e.g., PD-1, PD-L1, PD-L2) and/or PD-1/PD-L1 regulatory factors including AP-1 and NFκB family members in skin tissue of individuals to determine an individual's 1) risk for skin cancer development and 2) appropriate prophylactic treatment strategy to prevent skin cancer development. This information will facilitate identification of those patients at risk for pre-malignant (or pre-cancerous) skin lesions or subsequent NMSC lesions who would benefit from a PD-1/PD-L1 pathway suppressing therapy to prevent skin cancer development.

Method of determining risk for skin cancer development and skin cancer therapeutic prevention by measuring PD-1/PD-L1 signaling pathway members

An imaging station/booth for automated total body imaging having a small footprint and capable of quickly, efficiently, effectively, and consistently capturing multiple body images of a user or patient over time with minimal assistance from medical staff.

System and apparatus for automated total body imaging

A viewing navigation grid and imaging display especially useful for viewing recorded skin images.

Viewing grid and image display for viewing and recording skin images

Imaging booth

Embodiments of an imaging station and method for repeatable alignment of images are generally described herein. In some embodiments, the imaging station includes a rotatable stage and a monostand. The rotatable stage may include a structure to support sets of handles for positioning of a subject's hands for at least some of the body poses. A camera is positioned on the monostand for capturing images of the subject and is configured to allow the camera to be repeatably positioned with respect to the rotatable stage for each body pose.

Imaging station and method for repeatable alignment of images

Growing community of inventors

Tucson, AZ, United States of America

Clara Curiel