Almac Diagnostics Limited

Almac Diagnostic Services Limited

Claire Trinder

Richard Kennedy

Timothy Davison

Denis Paul Harkin

Max Bylesjo

Vitali Proutski

Andreas Winter

Laura A Hill

Fionnuala Patterson

Katherine E Keating

Steve Deharo

Jude O'Donnell

Andrena McCavigan

Charlie Gourley

Eamonn J O'Brien

Caroline Michie

Julie Clarke

Peter Kerr

Vadim Farztdinov

Robert James Holt

Dennis Paul Harkin

Eamonn J O'BRIEN

Andrena Mccavigan

Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that have an up-regulation or a down-regulation in biomarker expression related to angiogenesis and vascular development. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Molecular diagnostic test for cancer

Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent

A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful for determining the prognosis of a patient diagnosed with colon cancer, such as stage II colon cancer. The gene signature described herein is also useful for determining effectiveness of surgical resection with or without adjuvant chemotherapy, and determining possibility of cancer recurrence in patients with colon cancer.

Colon cancer gene expression signatures and methods of use

Growing community of inventors

Stratford-Upon-Avon, United Kingdom

Claire Trinder