Centre National De La Recherche Scientifique-Cnrs

Institut Pasteur De Lille

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Centre Hospitalier Régional Universitaire De Lille

Universitë{umlaut Over ( )}De Lille

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université De Lille

Claire Montpellier

Jean Dubuisson

Laurence Cocquerel-Deproy

Anne Goffard

Hepatitis E virus (HEV) is responsible for over 50% of acute viral hepatitis cases worldwide. The inventors have now identified the precise sequence of infectious particle-associated ORF2 capsid protein. Strikingly, their analyses revealed that in infected patients, HEV produces three forms of the ORF2 capsid protein: ORF2i, ORF2g and ORF2c. The ORF2i protein is associated with infectious particles whereas ORF2g and ORF2c proteins are massively produced glycoproteins that are not associated with infectious particles and are the major antigens present in HEV-infected patient sera. Accordingly, the ORF2i and ORF2g proteins are thus the subject matter of the present invention as well as antibodies specific for the proteins and diagnostic assays (e.g. ELISA) for the diagnosis of Hepatitis E virus infection.

Hepatitis E virus ORF2 capsid polypeptides and uses thereof

Growing community of inventors

Lille, France

Claire Montpellier