Amgen Inc.

Claire L M Jackson

Bin Wu

Liping H Pettus

Ryan Paul Wurz

Bradley J Herberich

Andrew Stewart Tasker

Anthony B Reed

Victor J Cee

Brian Alan Lanman

Hui-Ling Wang

Mark Henry Norman

Nuria A Tamayo

Thomas Nixey

Adrian Leonard Smith

Frank Chavez

Jian Jeffrey Chen

Thomas T Nguyen

Nobuko Nishimura

Longbin Liu

Shon Booker

Kevin Chao Yang

Robert Michael Rzasa

Shannon Rumfelt

Kaustav Biswas

Derin C D'amico

Fang-Tsao Hong

Noel D'Angelo

Matthew Lee

Yunxin Y Bo

Seifu Tadesse

Essa Hu Harrington

Kristin L Andrews

Hongyu Liao

Adrian L Smith

The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

Amides as pim inhibitors

The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

Azole compounds as PIM inhibitors

The invention relates to bicyclic compounds of formulas I and I', and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

Bicyclic pyridazine compounds as Pim inhibitors

The invention relates to bicyclic compounds of formula (1'), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer. 

Bicyclic compounds as Pim inhibitors

The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.

Inhibitors of PI3 kinase and/or mTOR

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Thousand Oaks, CA, United States of America

Claire L M Jackson