Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Lead Discovery Center Gmbh

Sotio A.s.

Claes M Gustafsson

Tim Bergbrede

Nils-Göran Larsson

Maria Falkenberg-Gustafsson

Uwe Koch

Peter Nussbaumer

Bert Klebl

Axel Choidas

Raffaella Di Lucrezia

Anke Unger

The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as forster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.

Method to detect activity of a polymerase

The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

4-phenyl-coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

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Mölndal, Sweden

Claes M Gustafsson