Chiesi Farmaceutici S.p.a.

Shire Pharmaceuticals Ireland Limited

Zymenex A/s

Claes Andersson

Jens Fogh

Pia Hydén

Cecilia Weigelt

Stefan Nilsson

Helena Reuterwall

Christer Moller

Kurt Von Figura

Kerstin Lundell

Magnus Hjertman

Pia Ringholm Gulstad

Christer Môller

Diego Prieto Roces

Meher Irani

Christer MØLLER

The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.

Process for production and purification of recombinant lysosomal alpha-mannosidase

The present invention relates to an animal model for infantile globoid cell leucodystrophy, and use of said animal model for screening and/or validation of agents which may be useful as a medicament for treatment of globoid cell leukodystrophy.

Animal model of Krabbe's disease

The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject. A final aspect of the invention provides a method of treating a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising a rhASA and thereby obtaining a reduction in the galactosyl sulphatide levels in target cells within said subject.

Production and purification of recombinant arylsulfatase A

Production and purification of recombinant arylsulftase

A process for purification of recombinant porphobilinogen deaminase (rhPBGD) on an industrial scale by starting from a rhPBGD containing extract obtained from a fermentation of a recombinant cell capable of expressing the rhPBGD and the use of the purified product for the preparation of a medicament.

Process for purification of recombinant porphobilinogen deaminase

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Täby, Sweden

Claes Andersson