University of Virginia Patent Foundation

North Carolina State University

Cirle Alcantara Warren

Richard Littleton Guerrant

Todd Robert Klaenhammer

Michael Paul Timko

Nathan Swami

Vahid Farmehini

Evelyn Durmaz

Ali Rohani

Yi-Hsuan Su

Glynis L Kolling

John Hudson Moore, Ii

Edward Van Opstal

Systems, methods, and devices are described herein for identifying, monitoring, isolating, or selecting a cell having a predefined characteristic in a mixed population of cells utilizing a combination of any one or more of iDEP, a region of localized field enhancement, a variable frequency electric field, a wide bandwidth amplifier, and/or an imaging apparatus.

Amplifier system and controls for dielectrophoretic tracking in microfluidic devices

infection (CDI) is the most common cause of antibiotic-associated diarrhea. Unfortunately, antibiotic therapy remains as the standard treatment for this antibiotic-induced disease and relapses are common. Antibiotic treatment typically is given for 10 to 14 days for initial or second episode of CDI. For recurrent episodes, more prolonged courses are recommended. It is disclosed herein that lower dose or shorter course of the antimicrobial treatment is sufficient to treat the disease and prevent recurrent disease by enabling a good immunologic response to infection, and perhaps also by better preserving normal flora, thus protecting against relapses or reinfection.

Compositions and methods for treating clostridium infection and preventing recurrence of infection

Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitivebacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by thebacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject abacterium modified to release a biotherapeutic agent following bile exposure. Administration of thebacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders includinginfection and antibiotic-associated diarrhea.

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Cirle Alcantara Warren