Cardiome Pharma Corp.

Ballard Power Systems Corporation

Cindy J Longley

Gregory N Beatch

Michael J A Walker

Richard A Wall

Bertrand M C Plouvier

Jeff Jiqun Zhu

Tao Sheng

Alexander B Zolotoy

Sandro L Yong

Allen I Bain

David P Wilkinson

Jean St-Pierre

Joy A Roberts

Kevin M Colbow

Clarence Y Chow

Jiujun Zhang

Peter Urban

Marian E Van Der Geest

Erik Paul Johannes

Jens M&uuml;ller

John Ka Chan

Regina Wezel

By Patricia Allan, Administrator

Derek E Allan, Deceased

Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.

Ion channel modulating compounds and uses thereof

Aminocycloalkyl cinnamide compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.

Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics

Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia. n=1&#x2013;4; R, R, R, R, R, R, X and A are as in claim ().

Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics

An electrochemical fuel cell is operated with periodic reactant starvation at either or both electrodes. Periodic reactant starvation conditions cause a change in the potential of the starved electrode and may result in the removal of electrocatalyst poisons and in improved fuel cell performance. This technique may have other beneficial effects at the electrodes, including performance improvements due to water management effects or localized heating effects at the starved electrode. In a preferred method, while successive localized portions of a fuel cell electrode are periodically reactant starved, the remainder of the fuel cell electrode remains electrochemically active and saturated with reactant such that the fuel cell is able to continue to generate power.

Method and apparatus for operating an electrochemical fuel cell with periodic reactant starvation

A method and apparatus is provided for operating an electrochemical fuel cell with periodic momentary fuel starvation at the anode. It is believed that such momentary periodic fuel starvation conditions cause the anode potential to increase, resulting in the oxidation and removal of electrocatalyst poisons from the anode electrocatalyst and improved fuel cell performance. In a preferred method, while successive localized portions of the fuel cell anode are momentarily periodically fuel starved, the remainder of the fuel cell anode remains electrochemically active and saturated with fuel such that the fuel cell is continually available to generate power.

Method and apparatus for operating an electrochemical fuel cell with

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Vancouver, Canada

Cindy J Longley