Zymogenetics, Inc.

Other

The University of New Mexico

Novo Nordisk A/s

Ppl Therapeutics

Cindy A Sprecher

Donald C Foster

Angela K Hammond

Scott R Presnell

Jane A Gross

Julia E Novak

Stacey R Dillon

Richard D Holly

Andrew J Nelson

Joseph Leon Kuijper

Janet V Johnston

Francis J Grant

Maria M Dasovich

Theodore E Whitmore

Zeren Gao

Mark F Maurer

Walt Kisiel

James William West

Brian A Fox

Wenfeng Xu

Mark W Rixon

James D Kelly

Rolf E Kuestner

Cameron Brandt

Karen L Madden

Kjeld E Norris

James W Baumgartner

Frank J Grant

Stephen R Jaspers

Ole Hvilsted Olsen

Yasmin A Chandrasekher

Lars Christian Petersen

Fanny Norris

Kjeld Norris

Penny Thompson

Hal Blumberg

So Slashedren Bjo Slashedrn

Ian Robert Cottingham

Ian Garner

Donna E Prunkard

Simon M Temperley

Cameron S Brandt

Maribeth A Eagan

Julie E Novak

Xu Wenfeng

Maribeth A Eagen

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Methods of producing a zcytor17 heterodimeric cytokine receptor

ZCYTOR17 heterodimeric cytokine receptor

The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Polynucleotides encoding ZCYTOR17 ligand antibodies

Method of treating atopic dermatitis with antibody to zcytor17 ligand

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Polynucleotides encoding antibodies to cytokine receptor zcytor17

ZCYTOR17 heterodimeric cytokine receptor polynucleotides

Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

Cytokine zalpha11 ligand

Antibodies to cytokine receptor ZCYTOR17

Cytokine zalpha11 ligand antibodies

A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

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Seattle, WA, United States of America

Cindy A Sprecher