University of Sharjah

Cijo George Vazhappilly

Taleb H Altel

Raafat A El-Awady

Hany A Omar

Srinivasulu Vunnam

A compound represented by following formula I: according to the present disclosure. The disclosed compound is useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for preparations and methods for pharmaceutical applications, for example, as anticancer agents. The compound was found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compound also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, the compound represented by Formula I targets multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.

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Sharjah, United Arab Emirates

Cijo George Vazhappilly