Other

University College Dublin

American Biogenetic Sciences, Inc.

Daiichi Pharmaceutical Co., Ltd.

Ciaran M Regan

Heinz Nau

Jacob Szmuszkovicz

Tadashi Shiotani

Lisa Conboy

Shane Gannon

David O'Gorman

Alan O'Connell

The invention provides a selective Sigma 1 or Dopamine D3 receptor agonist or a 5HT2c receptor ligand for use in the treatment of symptoms of anxiety and/or depression associated with an affective disorder and/or symptoms associated with cognitive impairment disorder. Particularly useful are diphenhydramine derivatives of Formula (I) and particularly (2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethyl-ethanamin) (Captodiamine).

Psycho-pharmaceuticals

Benzo&lsqb;b&rsqb;quinolizidine and benzo&lsqb;f&rsqb;indolizidine derivatives are provided which are useful for the treatment of Alzheimer's disease, senile dementia or other conditions characterized by memory loss. Pharmaceutical compositions containing these compounds, and methods for their use, are also provided.

Benzoquinolizidine and benzoindolizidine derivatives and therapeutic uses thereof

Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.

Antiproliferative and neurotrophic molecules

A medicament comprising as an active ingredient a compound represented by the following formula: R,&mdash;CH,CONH&mdash;R,wherein R,represents pyridyl group, a substituted pyridyl group, phenyl group, or a substituted phenyl group; and R,represents a 2-oxo-1-phyrrolidinyl group which may be substituted (e.g., N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide), which is useful for preventive and/or therapeutic treatment of amnesia caused by, for example, an anesthetic agent for intravenous administration such as propofol.

Prophylactic or therapeutic agent for amnesia

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Dublin, Ireland

Ciaran M Regan