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Guangzhou Institute of Respiratory Disease

The First Affiliated Hospital of Guangzhou Medical University

Chuqin Huang

Kefang Lai

Shan Zhong

Xiaodong Liu

Bonian Zhong

The invention discloses a use of asarinin in preparation of medicines for treating various coughs. The asarinin is used for preparing medicines for treating various coughs separately or in combination with other medicines. The asarinin can be extracted by an SFE-CO2 method. The asarinin and usable drug carriers or excipients are made into various formulations. And the formulations are granules, tablets, capsules, soft capsules, pills, dripping pills, ointments, syrups, injection, oral liquid, tinctures, sustained-releasing drugs, controlled release drugs or targeting preparations.

Use of asarinin in preparation of medicines for treating various coughs

The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crudepowder in an SFE-COdevice; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70&#xb0; C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50&#xb0; C. and the flow rate of COis 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of; standing the total volatile oil offor 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.

Method for extracting high-purity asarinin by supercritical carbon dioxide extraction method and use thereof

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Guangzhou, China

Chuqin Huang