23andme, Inc.

Coursera, Inc.

Chuong Do

John Michael Macpherson

Eric Durand

Brian Thomas Naughton

Joanna Louise Mountain

Emily Glassberg Sands

Kang Chen

Eric Yves Jean-Marc Durand

Nicholas Eriksson

Hyun Bin Kim

Airong Cai

Ancestry deconvolution includes obtaining unphased genotype data of an individual; phasing, using one or more processors, the unphased genotype data to generate phased haplotype data; using a learning machine to classify portions of the phased haplotype data as corresponding to specific ancestries respectively and generate initial classification results; and correcting errors in the initial classification results to generate modified classification results.

Scalable pipeline for local ancestry inference

Databases and data processing systems for use with a network-based personal genetics services platform may include member information pertaining to a plurality of members of the network-based personal genetics services platform. The member information may include genetic information, family history information, environmental information, and phenotype information of the plurality of members. A data processing system may determine, based at least in part on the member information, a model for predicting a phenotype from genetic information, family history information, and environmental information, wherein determining the model includes training the model using the member information pertaining to a set of the plurality of members. The data processing system may also receive a request from a questing member to predict a phenotype of interest, and apply an individual's genetic information, family history information, and environmental information to the model to obtain a prediction associated with the phenotype of interest for the requesting member.

Database and data processing system for use with a network-based personal genetics services platform

In one general aspect, a computer-implemented method can include receiving, by a computer system, a name for a course, receiving, by the computer system, a selection of a skill, storing, in a first database included in the computer system, the skill tagged to the course, creating a skills graph including tagged skills for a plurality of courses including the course, the skills graph providing a graph of a skills hierarchy for the course, storing, in a second database included in the computer system, the skills graph, receiving, by the computer system, a query for the skill, and in response to receiving the query, traversing the skills graph, the traversing identifying the skill as a tagged skill for at least the course, and based on identifying the skill as a tagged skill for the course, identifying the name for the course.

Content discovery using a skills graph

Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Ancestry painting with local ancestry inference

Error correction in ancestry classification includes obtaining, from a classifier, initial ancestry classifications associated with portions of two phased haplotypes of a chromosome pair of an individual; performing error correction on an initial ancestry classification, including detecting a phasing error in the initial ancestry classifications; and outputting a corrected ancestry classification in which the phasing error is corrected.

Error correction in ancestry classification

Phasing unphased genotype data of an individual includes: obtaining the unphased genotype data of the individual; processing the unphased genotype data to determine phased haplotype data, the processing comprising performing out-of-sample population-based phasing on the unphased genotype data; wherein: performing out-of-sample population-based phasing includes performing statistical analysis using predetermined reference data that is based on genotype data of a reference population; and the genotype data of the reference population does not reference the genotype data of the individual.

Growing community of inventors

Mountain View, CA, United States of America

Chuong Do