The University of Texas System

Immunesensor Therapeutics, Inc.

Other

Immune Sensor, LLC

Chuo Chen

Lijun Sun

Zhijian Chen

Heping Shi

Qi Wei

Jian Qiu

Youtong Wu

Lawrence Lum

Boyu Zhong

Jiaxi Wu

Matt Tschantz

Jing Li

Huiling Tan

Wei Tang

Michael G Roth

Baozhi Chen

Michael E Dodge

Yuanwei Dai

Mi Deng

Chengcheng Zhang

Junke Zheng

Ozlem Kulak

Nageswari Yarravarapu

Lin You

Chengwei Zhang

Xiaolei Wang

Lishu Zhang

Xuewu Zhang

Xiaofeng Wu

Yi Liu

Jiawei Liu

Hulling Tan

Mike Roth

Michael Dodge

The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

Antibody-sting agonist conjugates and their use in immunotherapy

The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Quinoline cGAS antagonist compounds

Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

cGAS antagonist compounds

CGAS antagonist compounds

Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2'3-cGAMP, 2&#x2032;2-cGAMP, 3&#x2032;2&#x2032;-cGAMP and 3&#x2032;3&#x2032;-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Cyclic di-nucleotide compounds and methods of use

Antibody-STING agonist conjugates and their use in immunotherapy

The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.

Compounds supports hematopoietic stem cells and red blood cells

The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit the Wnt pathway and used to treat cancer, myocardial infarction, osteopetrosis, or used in the maturation of a precursor cell to a mature cell. Also provided herein in are pharmaceutical compositions of the compounds described herein. 

Disubstituted and trisubstituted 1,2,3-triazoles as Wnt inhibitors

Growing community of inventors

Dallas, TX, United States of America

Chuo Chen