Xiamen University

Xiamen Innovax Biotech Co., Ltd.

Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.

Chunyan Yang

Ningshao Xia

Shaowei Li

Ying Gu

Jun Zhang

Wenxin Luo

Jin Wang

Cuiling Song

Yun Zhang

The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.

Truncated L1 protein of human papillomavirus type 11

Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.

Fusion protein comprising diphtheria toxin non-toxic mutant CRM197 or fragment thereof

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Xiamen, China

Chunyan Yang