Massachusetts Institute of Technology

Leland Stanford Junior University

Chunte Peng

Steven Chu

John M Essigmann

Andrei Tokmakoff

Bogdan I Fedeles

Vipender Singh

Yunxiang Zhang

Qian Liu

An upconversion single molecule probe is provided that includes a core having a nanoparticle seed crystal, where the nanoparticle seed crystal is an upconversion seed crystal, a first shell enveloping the core, and a second shell enveloping the first shell.

Ultrabright lanthanide-doped nanoparticles

The present disclosure provides nucleoside analogs of Formula (I) or (II). The nucleoside analogs are expected to show multiple tautomerism and may increase the mutation of an RNA and/or DNA (be mutagenic) of a virus or cancer cell. The multiple tautomerism and mutagenesis of the nucleoside analogs may be adjusted by substituting the nucleoside analogs with one or more electron-donating groups and/or electron-withdrawing groups to increase or decrease the pK(e.g., to a pKbetween 5.5 or 8.5). The present disclosure also provides pharmaceutical compositions and kits including the nucleoside analogs and methods of treating a viral infection (e.g., influenza, HIV infection, or hepatitis) or cancer using the nucleoside analogs, pharmaceutical compositions, or kits.

Mutagenic nucleoside analogs and uses thereof

Growing community of inventors

Mountain View, CA, United States of America

Chunte Peng