Medispectra, Incorporated

Other

Analogic Corporation

Chunsheng Jiang

Kevin Schomacker

Ross Flewelling

Philippe Schmid

Charles C Abele

Thomas J Clune

Christopher E Griffin

Alex R Zelenchuk

Jean-Pierre Schott

Richard M Morrell

Thomas M Meese

Perry S Banks

Karen M Twietmeyer

The invention provides methods of focusing an instrument for the acquisition of optical data from a tissue sample. Methods of the invention allow rapid focusing in the context of a diagnostic procedure in which rapid data acquisition is desirable. For example, inventive methods allow a user to focus an optical instrument quickly enough to obtain data within an optimal window of time following application of a chemical agent to the tissue. In one embodiment, a user focuses an optical instrument by aligning laser spots projected onto a tissue sample within rings that are superimposed at predetermined locations within the user's visual field. Preferred methods of the invention further comprise automatic validation to detect whether the spots are sufficiently well-aligned.

Methods and apparatus for evaluating image focus

The invention provides methods of determining a correction for a misalignment between at least two images in a sequence of images due at least in part to sample movement. The methods are applied, for example, in the processing and analysis of a sequence of images of biological tissue in a diagnostic procedure. The invention also provides methods of validating the correction for a misalignment between at least two images in a sequence of images of a sample. The methods may be applied in deciding whether a correction for misalignment accurately accounts for sample motion.

Methods and systems for correcting image misalignment

The invention provides methods for processing tissue-derived spectral data for use in a tissue classification algorithm. Methods of the invention comprise application of spectral and/or image masks for automatically separating ambiguous or unclassifiable spectral data from valid spectral data. The invention improves the accuracy of tissue classification, in part, by properly identifying and accounting for spectral data from tissue regions that are affected by an obstruction and/or regions that lie outside a diagnostic zone of interest.

Methods and apparatus for processing spectral data for use in tissue characterization

The invention provides methods for displaying diagnostic results obtained from a tissue sample. In general, the invention assigns tissue-class probability values to discrete regions of a patient sample, and creates an overlay for displaying the results. The overlay facilitates display of the tissue class probabilities in a way that reflects the diagnostic relevance of the data. For example, methods of the invention comprise applying filtering and color-blending techniques in order to facilitate display of diagnostic results.

Methods and apparatus for displaying diagnostic data

An improved ROI segmentation image processing system substantially masks non-ROI image data from a digital image to produce a ROI segmented image for subsequent digital processing. The ROI segmentation image processing system is a computer-based system having a collimation subsystem configured to detect and mask out collimated regions within the image. Furthermore, a direct exposure (DE) subsystem is configured to detect and remove DE regions from the image. Holes generated in the image are filled-in to provide a resulting image with only ROI.

ROI segmentation image processing system

Growing community of inventors

Reading, MA, United States of America

Chunsheng Jiang