Geneohm Sciences, Inc.

Genvault Corporation

Gentegra LLC

Genohm Sciences

Chunnian Shi

Honghua Zhang

Donald M Crothers

R Erik Holmlin

Michael E Hogan

David Wong

Michael Saghbini

Erik R Holmlin

The present invention provides compositions useful for biomolecule storage comprising a water soluble inorganic compound, a stabilizer, or a combination thereof. The present invention also provides methods of using the compositions of the invention to store biomolecules in the dry state and in solution, as well as sample carriers and kits comprising compositions of the invention.

Matrices and media for storage and stabilization of biomolecules

The present disclosure provides methods and compositions for conducting an assay to detect a polynucleotide. In particular, ruthenium complexes having reduction potentials that do not coincide with the reduction potential of molecular oxygen are disclosed and amperometric techniques for their use are described. In preferred embodiments, the ruthenium complex is ruthenium (III) pentaamine pyridine and the polynucleotide that is detected is DNA. Further, techniques for enhancing detectable contrast between hybridized and unhybridized nucleic acids are disclosed. In particular, the use of elongated target strands as well as the use of uncharged probe strands are discussed.

Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen

Provided herein are compositions and methods for enhancing the relative efficiency of hybridization between target nucleic acids and capture probes compared to target variants and capture probes.

Inhibition of mismatch hybridization by a universal competitor DNA

The present disclosure provides methods and compositions for conducting an assay to detect nucleic acid hybridization in the presence of oxygen. In particular, ruthenium complexes having a reduction potential that does not coincide with the reduction potential of molecular oxygen are disclosed and amperometric techniques for their use are described. In preferred embodiments, the ruthenium complex is ruthenium (III) pentaamine pyridine and the nucleic acid hybridization event that is detected is DNA hybridization. Further, techniques for enhancing detectable contrast between hybridized and unhybridized nucleic acids are disclosed. In particular, the use of elongated target strands as well as the use of uncharged probe strands are discussed.

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San Diego, CA, United States of America

Chunnian Shi