Dow Global Technolgoies LLC

Chinese Academy of Sciences

Qilu Pharmaceutical Co., Ltd.

Chunliu Zhu

Yong Gan

Ka Chun A Chan

Qingmin Yang

Shiyan Guo

Sophie Zhai

Xiaoqing Zheng

Li Gan

Xinxin Zhang

Robert I Schmitt

Quanlei Zhu

Sustained release dosage form

A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof

Growing community of inventors

Shanghai, China

Chunliu Zhu