Hoffmann-la Roche Inc.

Shanghai United Imaging Healthcare Co., Ltd.

F. Hoffmann-la Roche Ag

Chunlin Zhao

Xin-Jie Chu

Lei Zhang

Binh Vu

Wenjun Yu

Ce Wang

David Joseph Bartkovitz

Allen John Lovey

Li Chen

Jin-Jun Liu

Hongju Li

Jianping Cai

George Kenneth Ehrlich

Daniel Vincent Fishlock

Hanspeter Michel

Binh Thanh Vu

George Ehrlich

The present disclosure provides computer-aided diagnosis systems and methods. The method may include obtaining multiple medical images of one or more bones; for at least one of the multiple medical images, detecting one or more bone fracture regions of the one or more bones in the medical image; causing a management list to be displayed for managing the one or more bones; receiving an instruction related to selecting at least one of the one or more bones, the instruction being generated through the management list; and upon receiving the instruction, causing the following to be displayed: at least one of one or more reconstructed bone images related to the at least one selected bone; or a marker of the one or more detected bone fracture regions related to the at least one selected bone.

Systems and methods for image processing

The present disclosure provides computer-aided diagnosis systems and methods for detecting bone fracture. The method may include obtaining one or more medical images related to one or more bones. The method may also include obtaining a fracture detection model generated based on a machine learning model. The method may also include detecting, for at least one of the one or more medical images, one or more bone fracture regions of the one or more bones in the medical image using the fracture detection model.

There are provided compounds of the formula wherein X, Y, Z, R, Rand Rare as described hereinand enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

Substituted pyrrolidine-2-carboxamides

There are provided compounds of the formula wherein X, Y, Z, R, R, Rand Rare as described hereinand enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

There are provided compounds of the formula or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V, V, R, R, R, Rand Rare herein described. These compounds are useful as anticancer agents.

Chiral cis-imidazolines

Novel 4-aminothiazole derivatives are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminothiazole derivatives.

4-Aminothiazole derivatives

Growing community of inventors

Shanghai, China

Chunlin Zhao