Qingdao Harwars Biology Group Ltd.

Chunlin Yi

Jie Yang

Gang Liu

Zhen Yang

Hongshang Chang

Zongke Wang

Bingbing Zhao

Fenglong Ma

Mingyi Li

Yujie Xia

Xiaochen Cui

A paramyxovirus vaccine strain for novel coronavirus pneumonia and a construction method thereof are provided. The method includes performing a recombination of N and F genes of Newcastle disease virus type VII of Paramyxoviridae with P, M, H, L genes of Canine distemper virus of Paramyxoviridae to obtain a recombinant virus, inserting S1 gene of the novel coronavirus between the P and M genes of the recombinant virus to obtain a recombinant vector. The vaccine strain constructed can stably and efficiently express the novel coronavirus S1 protein, and induce the body to produce antibodies; and the recombined virus vaccine strain can stimulate the human body to produce mucosal immunity, and the prepared vaccine can be vaccinated through a nasal spray. Moreover, the vaccine strain can be tested in poultry and dogs, saving time, reducing costs, and being more conducive to actual production due to large output.

Paramyxovirus vaccine strain for novel coronavirus pneumonia and construction method thereof

Growing community of inventors

Qingdao, China

Chunlin Yi