Ethicon Endo-surgery, Inc.

Ethicon, Gmbh

Janssen Biotech, Inc.

Advanced Technologies and Regenerative Medicine, LLC

Cordis Corporation

Codman & Shurtleff, Inc.

Mentor Worldwide LLC

Cilag International Gmbh

Fibrogen, Inc.

Chunlin Yang

Charles J Scheib

Taylor W Aronhalt

Frederick E Shelton, IV

Jeffrey L Aldridge

Cortney E Henderson

Katherine J Schmid

Joseph Henry Contiliano

Venkataramanan Mandakolathur Vasudevan

Jeffrey S Swayze

Michael S Cropper

Yufu Li

Iksoo Chun

Chester O Baxter, Iii

Eugene L Timperman

Tamara S Widenhouse

Donna L Korvick

Ying Sun

Christopher J Schall

Mark D Timmer

John Wheeler

William Bruce Weisenburgh, Ii

Richard L Leimbach

Rao S Bezwada

Richard William Timm

Sean P Conlon

Bruce E Maryanoff

Steven G Hall

Darren R Sherman

Gary W Knight

William Alvin Kinney

Christopher W Widenhouse

Joshua R Uth

Anna Gosiewska

Mark H Ransick

Kevin L Cooper

Ilya S Koyfman

Gene W Kammerer

John Kehoe

Carrie H Fang

Daphne Ann Salick Ryan

Abla A Creasey

Thomas Matalenas

Raymond S Shissias

Kerstin Spychaj

Stephen Wohlert

Sridevi N Dhanaraj

Agnieszka Seyda

Yi-Lan Wang

Guanghui Zhang

John L Stammen

Qiang Zhang

Hiep Quang Do

Andrew C Yoo

David C Colter

Charito S Buensuceso

Stephanie A Mutchler

Richard Champion Davis, Iii

David R Olsen

Hiep Do

James E Hauschild

Robert Vetrecin

Philip M Steele

Mabel Alarnino Cejas

Daphne A Salick

James W Polarek

Abla Creasy

Jennifer Hagyoung Kang Choi

Ziwei Wang

Matthew Gounis

Thoppil Mathew John

Wei Kong

Ii William B Weisenburgh

Iii Chester O Baxter

Joseph Hammer

Abla Creasey

Kelly R Arnold

Richard Champion Davis Iii

Mabel Alamino Cejas

In various embodiments, an end effector comprising a first jaw, a second jaw, an implantable arrangement, first cavities, and second cavities is disclosed. At least one of the first and second jaws is movable to compress tissue between the first jaw and second jaws. The implantable arrangement comprises a first layer and a second layer. The first layer and the second layer comprise a polymeric composition. The first cavities are defined in the first layer and interconnectedly form a permeable first layer. The first cavities releasably retain a first therapeutic agent configured to induce a first biological response in the tissue. The second cavities are defined in the second layer and interconnectedly form a permeable second layer. The second cavities releasably retain a second therapeutic agent configured to induce a second biological response in the tissue. The first therapeutic agent and the second therapeutic agent are different.

End effector including an implantable arrangement

A fastening system for fastening tissue that comprises a cartridge and an implant is disclosed. The cartridge comprises a cartridge body comprising removable fasteners. The implant comprises a first portion comprising a first absorbable polymer comprising a first compactness of first fibers and a first medicament releasably stored in the first compactness of the first fibers of the first portion. The implant further comprises a second portion comprising a second absorbable polymer comprising a second compactness of second fibers, wherein the second compactness is different than the first compactness. The second absorbable polymer is different than the first absorbable polymer. The implant further comprises a second medicament releasably stored in the second compactness of the second fibers of the second portion. The second medicament is different than the first medicament. The release of the second medicament and the release of the first medicament co-operatively produce a healing result.

Stapling system comprising implantable layers

A tissue thickness compensator comprising at least one woven lattice can be positioned in the end effector of a surgical instrument. A fastener cartridge that is positioned in the end effector can comprise at least one cavity configured to receive a fastener. The fastener can be moveable between an initial position, wherein the fastener is at least partially position in a cavity, and a fired position, wherein the fastener is configured to compress a woven lattice of the tissue thickness compensator. The woven lattice can comprise a resilient material such that compression of the woven lattice generates a restoring force. The woven lattice can also comprise an axis that can laterally traverse the fastener cartridge, diagonally traverse the fastener cartridge, or intersect a deck surface of the fastener cartridge. The woven lattice can comprise a hydrophilic substance, which can expand when the woven lattice is severed by a cutting element.

Tissue thickness compensator comprising resilient members

An end effector is disclosed. The end effector comprises a first jaw, a second jaw, wherein at least one of the first jaw and the second jaw is movable to compress tissue between the first jaw and the second jaw, and a cartridge body configured to receive a cutting member. The end effector further comprises a layer arrangement including a tissue contact surface and a plurality of therapeutic agents releasably contained within the layer arrangement, wherein each therapeutic agent is configured to either initially treat the tissue or sustainably treat the tissue in contact with the tissue contact surface, wherein one of the plurality of therapeutic agents is configured to be released by the cutting member, and wherein another of the plurality of therapeutic agents is configured to be released by an absorption process.

Tissue thickness compensators comprising therapeutic agents

A tissue thickness compensator can comprise a plurality of fibers. Such fibers can include a plurality of first fibers comprised of a first material and a plurality of second fibers comprised of a second material. A tissue thickness compensator can comprise a plurality of layers wherein each layer can be comprised of one or more medicaments. Certain embodiments are disclosed herein for manufacturing a tissue thickness compensator comprising fibers, for example.

Tissue thickness compensator comprised of a plurality of materials

A tissue thickness compensator may generally comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a third layer comprising a third medicament. The tissue thickness compensator may comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a reservoir comprising a third medicament disposed within the reservoir. The medicaments may be independently selected from a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a pharmaceutically active agent, a matrix metalloproteinase inhibitor, and combinations thereof. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.

Layered tissue thickness compensator

A staple cartridge assembly for use with a surgical stapler. The assembly has a cartridge body having a support portion with a plurality of staple cavities with openings. There is also a plurality of staples, wherein at least a portion of each the staple is removably stored within a the staple cavity. Each the staple is movable between an unfired position and a fired position, and is deformable between an unfired configuration and a fired configuration. The assembly also includes a compressible tissue thickness compensator configured to be captured within the staples. The compressible tissue thickness compensator at least partially covers the staple cavity openings. The compressed tissue thickness compensator is configured to assume different compressed heights within different the staples. The compressible tissue thickness compensator comprising a lyophilized foam having an oxygen generating agent embedded therein.

Tissue stapler having a thickness compensator incorporating an oxygen generating agent

A tissue thickness compensator may generally comprise a biocompatible material, a first component, and a second component, wherein the first component and second component form a reaction product to expand the tissue thickness compensator. The first component may comprise a first hydrogel precursor, the second component may comprise a second hydrogel precursor, and the reaction product may comprise a hydrogel. The reaction product may be formed in vivo and/or in situ by contacting the first component and the second component. The first component and/or second component may be encapsulated and configured to release the components when ruptured. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.

Expandable tissue thickness compensator

A tissue thickness compensator can comprise a plurality of layers. Various embodiments are disclosed herein for manufacturing a tissue thickness compensator. In certain embodiments, a tissue thickness compensator can comprise at least one medicament tube, capsule, and/or packet contained therein.

Tissue thickness compensator comprising a plurality of capsules

Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.

Tissue engineered blood vessel

A nonwoven compensator for an end effector of a surgical instrument can comprise a plurality of spring fibers dispersed throughout the nonwoven compensator. The nonwoven compensator can be positioned in the end effector such as adjacent to a deck surface of a fastener cartridge that is positioned in the end effector. When a fastener from the fastener cartridge is moved from an initial position to a fired position, the fastener can be configured to engage the nonwoven compensator. The fastener can compress a portion of the nonwoven compensator in a staple entrapment area defined by the fired staple. The spring fibers in the nonwoven compensator can comprise a resilient material and can be deformed when the fastener compresses a portion of the nonwoven compensator. Further, the nonwoven compensator can comprise non-spring fibers, a haemostatic material, and/or a homogenous absorbable polymer matrix.

Tissue thickness compensator comprising fibers to produce a resilient load

We have disclosed affinity peptides toward infliximab. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for infliximab.

Affinity peptides toward infliximab

In various embodiments, a tissue thickness compensator can comprise a compressible extracellular matrix and a bioabsorbable material dispersed within the extracellular matrix, wherein the bioapsorption of the bioabsorbable material is configured to leave behind channels in the extracellular matrix. The tissue thickness compensator can also comprise generation means for generating the ingrowth of tissue into the channels. In at least one embodiment, the tissue thickness compensator can comprise dissolvable wicking members which, when dissolved, can leave behind channels in the tissue thickness compensator. In certain embodiments, the tissue thickness compensator can comprise at least one rupturable capsule.

Tissue thickness compensator comprising a reservoir

Implantable medical devices having galvanic particulates are disclosed. The particulate may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The present invention further provides a combination of galvanic particulates with an aqueous gel, a method of making this combination, and a method of treatment using this combination. The devices and compositions may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, tissue regeneration promoting, and pain reduction or elimination.

Medical devices with galvanic particulates

Growing community of inventors

Belle Mead, NJ, United States of America

Chunlin Yang